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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 25.45
Human Site: T899 Identified Species: 35
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 T899 P S L K I E D T V F H V F D K
Chimpanzee Pan troglodytes XP_509678 958 109081 T899 P S L K I E D T V F H V F D K
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 T889 P S L K I E D T V F H V F D K
Dog Lupus familis XP_542610 1186 133310 T1127 P S L K I E D T V F H I F D K
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 T899 P S L R I E G T V F H V F D K
Rat Rattus norvegicus Q5U2P0 1054 120741 Q927 E W K P G S L Q R S Q N K I I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 T907 P S L K V E D T A F H M F D K
Chicken Gallus gallus XP_417016 963 109342 T902 P S L T V E D T T L C V F D K
Frog Xenopus laevis Q6GN11 1040 119148 Q915 R W V H G S L Q R L P A Q I V
Zebra Danio Brachydanio rerio A2RV18 1057 120333 Q919 E W K P G T L Q K Y S D K I I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 V916 H T Q R C G D V V F H S F D P
Honey Bee Apis mellifera XP_397381 980 112421 I875 H S Q T C G N I T F H T F D P
Nematode Worm Caenorhab. elegans Q17632 961 108768 V912 V K V N G D V V I K E L E P V
Sea Urchin Strong. purpuratus XP_787332 1412 160533 G1345 E E P S Q N A G D V K F R A F
Poplar Tree Populus trichocarpa XP_002303419 935 105261 G886 L T M R G D K G G G E W F V D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 G884 L T G K G E K G A G D W Y V D
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 N949 D N L T E D P N S A A F D E V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 100 93.3 N.A. 86.6 0 N.A. 80 66.6 0 0 N.A. 40 33.3 0 0
P-Site Similarity: 100 100 100 100 N.A. 93.3 0 N.A. 93.3 73.3 6.6 6.6 N.A. 53.3 40 26.6 0
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 6.6 N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: 33.3 N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 6 0 12 6 6 6 0 6 0 % A
% Cys: 0 0 0 0 12 0 0 0 0 0 6 0 0 0 0 % C
% Asp: 6 0 0 0 0 18 42 0 6 0 6 6 6 53 12 % D
% Glu: 18 6 0 0 6 48 0 0 0 0 12 0 6 6 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 48 0 12 59 0 6 % F
% Gly: 0 0 6 0 36 12 6 18 6 12 0 0 0 0 0 % G
% His: 12 0 0 6 0 0 0 0 0 0 48 0 0 0 0 % H
% Ile: 0 0 0 0 30 0 0 6 6 0 0 6 0 18 12 % I
% Lys: 0 6 12 36 0 0 12 0 6 6 6 0 12 0 42 % K
% Leu: 12 0 48 0 0 0 18 0 0 12 0 6 0 0 0 % L
% Met: 0 0 6 0 0 0 0 0 0 0 0 6 0 0 0 % M
% Asn: 0 6 0 6 0 6 6 6 0 0 0 6 0 0 0 % N
% Pro: 42 0 6 12 0 0 6 0 0 0 6 0 0 6 12 % P
% Gln: 0 0 12 0 6 0 0 18 0 0 6 0 6 0 0 % Q
% Arg: 6 0 0 18 0 0 0 0 12 0 0 0 6 0 0 % R
% Ser: 0 48 0 6 0 12 0 0 6 6 6 6 0 0 0 % S
% Thr: 0 18 0 18 0 6 0 42 12 0 0 6 0 0 0 % T
% Val: 6 0 12 0 12 0 6 12 36 6 0 30 0 12 18 % V
% Trp: 0 18 0 0 0 0 0 0 0 0 0 12 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 6 0 0 6 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _