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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 51.21
Human Site: Y106 Identified Species: 70.42
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 Y106 R N R S A P V Y K R I R D V T
Chimpanzee Pan troglodytes XP_509678 958 109081 Y106 R N R S A P V Y K R I R D V T
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 V103 Q E F S H I L V S T D F L L F
Dog Lupus familis XP_542610 1186 133310 Y334 R N R S A P V Y K R I R D V T
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 Y106 R N R S A P I Y K R I R D V T
Rat Rattus norvegicus Q5U2P0 1054 120741 Y100 H Q R G R R Q Y N K L R N L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 Y113 R N R S P P V Y K R I R D V I
Chicken Gallus gallus XP_417016 963 109342 Y107 R N R S A P V Y K R I R D V I
Frog Xenopus laevis Q6GN11 1040 119148 Y96 H Q R G R R Q Y K K L C S L L
Zebra Danio Brachydanio rerio A2RV18 1057 120333 Y97 H T R G R R H Y N R L R S L L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 Y104 K H R S S A I Y K R F N E I V
Honey Bee Apis mellifera XP_397381 980 112421 Y89 K H K S S L V Y K R L K N L I
Nematode Worm Caenorhab. elegans Q17632 961 108768 Y115 K A K A V P A Y K K M N S L C
Sea Urchin Strong. purpuratus XP_787332 1412 160533 Y231 K H R S L P S Y K R I R D L I
Poplar Tree Populus trichocarpa XP_002303419 935 105261 Y95 K N K N S A V Y G R I R N L I
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 Y92 K N R N R S V Y N R I R L L C
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 Y129 R N K S Y P V Y T R L R T L C
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 6.6 100 N.A. 93.3 20 N.A. 86.6 93.3 20 26.6 N.A. 33.3 33.3 20 60
P-Site Similarity: 100 100 26.6 100 N.A. 100 46.6 N.A. 86.6 93.3 40 40 N.A. 73.3 86.6 60 80
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 40 N.A. N.A. 46.6 53.3 N.A.
P-Site Similarity: 80 N.A. N.A. 66.6 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 0 6 30 12 6 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 18 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 6 0 42 0 0 % D
% Glu: 0 6 0 0 0 0 0 0 0 0 0 0 6 0 0 % E
% Phe: 0 0 6 0 0 0 0 0 0 0 6 6 0 0 6 % F
% Gly: 0 0 0 18 0 0 0 0 6 0 0 0 0 0 0 % G
% His: 18 18 0 0 6 0 6 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 6 12 0 0 0 53 0 0 6 30 % I
% Lys: 36 0 24 0 0 0 0 0 65 18 0 6 0 0 0 % K
% Leu: 0 0 0 0 6 6 6 0 0 0 30 0 12 59 18 % L
% Met: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % M
% Asn: 0 53 0 12 0 0 0 0 18 0 0 12 18 0 0 % N
% Pro: 0 0 0 0 6 53 0 0 0 0 0 0 0 0 0 % P
% Gln: 6 12 0 0 0 0 12 0 0 0 0 0 0 0 0 % Q
% Arg: 42 0 71 0 24 18 0 0 0 77 0 71 0 0 0 % R
% Ser: 0 0 0 65 18 6 6 0 6 0 0 0 18 0 0 % S
% Thr: 0 6 0 0 0 0 0 0 6 6 0 0 6 0 24 % T
% Val: 0 0 0 0 6 0 53 6 0 0 0 0 0 36 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 6 0 0 95 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _