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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIS3 All Species: 34.55
Human Site: Y121 Identified Species: 47.5
UniProt: Q9Y2L1 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2L1 NP_001121698.1 958 109003 Y121 N N Q E K H F Y T F T N E H H
Chimpanzee Pan troglodytes XP_509678 958 109081 Y121 N N Q E K H F Y T F T N E H H
Rhesus Macaque Macaca mulatta XP_001083933 948 107719 F118 R F F L S F S F R E T Y V E Q
Dog Lupus familis XP_542610 1186 133310 Y349 N N Q E K H F Y T F T N E H H
Cat Felis silvestris
Mouse Mus musculus Q9CSH3 958 108819 Y121 N N Q E K H F Y T F T N E H H
Rat Rattus norvegicus Q5U2P0 1054 120741 V115 K D A R H D C V L F A N E F Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514554 966 109727 Y128 N N F E K H F Y T F T N E H H
Chicken Gallus gallus XP_417016 963 109342 Y122 G N P E K H F Y S F T N E H H
Frog Xenopus laevis Q6GN11 1040 119148 I111 R D T R H D C I L F S N E F Q
Zebra Danio Brachydanio rerio A2RV18 1057 120333 V112 K D P R H D C V L F A N E F Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651246 982 112164 Y119 H D R T R N F Y V F V N E H H
Honey Bee Apis mellifera XP_397381 980 112421 Y104 N N V H R K F Y V F I N E H H
Nematode Worm Caenorhab. elegans Q17632 961 108768 F130 Y E D A K D R F H V F M N E F
Sea Urchin Strong. purpuratus XP_787332 1412 160533 Y246 A N E T K R F Y V F T N E H H
Poplar Tree Populus trichocarpa XP_002303419 935 105261 V110 D S P A R R F V V F S N E F H
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565418 933 104978 Y107 S N P A R Q F Y V F S N H V H
Baker's Yeast Sacchar. cerevisiae Q08162 1001 113688 R144 R D S D D H K R F I V F H N E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.1 73.6 N.A. 91.1 35.2 N.A. 86.4 81 35.3 33.1 N.A. 55 55 46 36.7
Protein Similarity: 100 99.7 96.7 77.7 N.A. 96.4 52.1 N.A. 93.3 90.4 53.6 52.9 N.A. 72.7 72 63.3 50.8
P-Site Identity: 100 100 6.6 100 N.A. 100 20 N.A. 93.3 80 20 20 N.A. 46.6 60 6.6 66.6
P-Site Similarity: 100 100 13.3 100 N.A. 100 26.6 N.A. 93.3 86.6 33.3 26.6 N.A. 80 66.6 13.3 73.3
Percent
Protein Identity: 46.8 N.A. N.A. 47.9 43.3 N.A.
Protein Similarity: 66.3 N.A. N.A. 65.7 61.9 N.A.
P-Site Identity: 33.3 N.A. N.A. 40 6.6 N.A.
P-Site Similarity: 60 N.A. N.A. 60 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 6 18 0 0 0 0 0 0 12 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 18 0 0 0 0 0 0 0 0 % C
% Asp: 6 30 6 6 6 24 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 6 6 36 0 0 0 0 0 6 0 0 77 12 6 % E
% Phe: 0 6 12 0 0 6 65 12 6 83 6 6 0 24 6 % F
% Gly: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 6 0 0 6 18 42 0 0 6 0 0 0 12 53 65 % H
% Ile: 0 0 0 0 0 0 0 6 0 6 6 0 0 0 0 % I
% Lys: 12 0 0 0 48 6 6 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 6 0 0 0 0 18 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % M
% Asn: 36 53 0 0 0 6 0 0 0 0 0 83 6 6 0 % N
% Pro: 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 24 0 0 6 0 0 0 0 0 0 0 0 24 % Q
% Arg: 18 0 6 18 24 12 6 6 6 0 0 0 0 0 0 % R
% Ser: 6 6 6 0 6 0 6 0 6 0 18 0 0 0 0 % S
% Thr: 0 0 6 12 0 0 0 0 30 0 48 0 0 0 0 % T
% Val: 0 0 6 0 0 0 0 18 30 6 12 0 6 6 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 6 0 0 0 0 0 0 59 0 0 0 6 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _