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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
27.88
Human Site:
Y197
Identified Species:
38.33
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
Y197
P
A
F
T
C
E
E
Y
V
K
S
L
T
A
N
Chimpanzee
Pan troglodytes
XP_509678
958
109081
Y197
P
A
F
T
C
E
E
Y
V
K
S
L
T
A
N
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
Y187
P
A
F
T
C
E
E
Y
V
K
S
L
T
A
N
Dog
Lupus familis
XP_542610
1186
133310
Y425
P
A
F
T
C
E
E
Y
V
K
S
L
T
A
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
Y197
P
A
F
T
C
E
E
Y
V
K
S
L
T
A
N
Rat
Rattus norvegicus
Q5U2P0
1054
120741
P194
N
Y
L
D
N
F
W
P
D
L
K
A
A
H
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
Y205
P
T
Y
T
C
E
E
Y
V
K
S
L
I
A
N
Chicken
Gallus gallus
XP_417016
963
109342
Y200
T
A
Y
T
C
E
E
Y
I
K
S
L
I
D
N
Frog
Xenopus laevis
Q6GN11
1040
119148
L207
K
S
L
R
D
T
H
L
E
R
K
L
E
S
R
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
G188
S
T
Q
E
Y
L
L
G
F
W
P
D
L
Q
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
A201
G
I
L
V
T
T
A
A
E
Y
V
K
S
L
E
Honey Bee
Apis mellifera
XP_397381
980
112421
E176
G
I
P
T
I
S
M
E
D
Y
I
L
S
L
E
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
Y202
H
V
M
Y
L
K
E
Y
I
Q
N
L
E
D
P
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
L328
A
M
E
G
R
P
E
L
M
D
R
L
A
Q
I
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
P188
Y
V
K
S
L
G
Q
P
A
L
L
D
L
L
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
P185
Y
V
K
S
L
G
Q
P
E
L
L
D
L
L
A
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
L224
S
L
V
Q
Y
I
E
L
L
P
N
A
D
D
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
80
66.6
6.6
0
N.A.
0
13.3
20
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
0
N.A.
86.6
80
26.6
0
N.A.
6.6
20
46.6
20
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
0
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
36
0
0
0
0
6
6
6
0
0
12
12
36
12
% A
% Cys:
0
0
0
0
42
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
6
6
0
0
0
12
6
0
18
6
18
0
% D
% Glu:
0
0
6
6
0
42
59
6
18
0
0
0
12
0
18
% E
% Phe:
0
0
30
0
0
6
0
0
6
0
0
0
0
0
0
% F
% Gly:
12
0
0
6
0
12
0
6
0
0
0
0
0
0
0
% G
% His:
6
0
0
0
0
0
6
0
0
0
0
0
0
6
0
% H
% Ile:
0
12
0
0
6
6
0
0
12
0
6
0
12
0
12
% I
% Lys:
6
0
12
0
0
6
0
0
0
42
12
6
0
0
0
% K
% Leu:
0
6
18
0
18
6
6
18
6
18
12
65
18
24
0
% L
% Met:
0
6
6
0
0
0
6
0
6
0
0
0
0
0
0
% M
% Asn:
6
0
0
0
6
0
0
0
0
0
12
0
0
0
42
% N
% Pro:
36
0
6
0
0
6
0
18
0
6
6
0
0
0
6
% P
% Gln:
0
0
6
6
0
0
12
0
0
6
0
0
0
12
0
% Q
% Arg:
0
0
0
6
6
0
0
0
0
6
6
0
0
0
6
% R
% Ser:
12
6
0
12
0
6
0
0
0
0
42
0
12
6
0
% S
% Thr:
6
12
0
48
6
12
0
0
0
0
0
0
30
0
0
% T
% Val:
0
18
6
6
0
0
0
0
36
0
6
0
0
0
6
% V
% Trp:
0
0
0
0
0
0
6
0
0
6
0
0
0
0
0
% W
% Tyr:
12
6
12
6
12
0
0
48
0
12
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _