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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
34.55
Human Site:
Y258
Identified Species:
47.5
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
Y258
F
R
A
S
R
E
N
Y
L
E
A
T
V
W
I
Chimpanzee
Pan troglodytes
XP_509678
958
109081
Y258
F
R
A
S
R
E
N
Y
L
E
A
T
V
W
I
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
Y248
F
R
A
S
R
E
N
Y
L
E
A
T
V
W
I
Dog
Lupus familis
XP_542610
1186
133310
Y486
F
R
A
S
R
E
N
Y
L
E
A
T
V
W
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
Y258
F
R
A
S
R
E
N
Y
L
E
A
T
V
W
I
Rat
Rattus norvegicus
Q5U2P0
1054
120741
A255
L
N
V
N
K
H
R
A
Q
I
E
A
F
V
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
Y266
F
R
A
S
R
E
N
Y
L
E
A
T
V
W
V
Chicken
Gallus gallus
XP_417016
963
109342
Y261
Y
R
A
S
R
E
N
Y
L
E
A
T
V
W
V
Frog
Xenopus laevis
Q6GN11
1040
119148
D268
G
L
G
G
K
E
T
D
I
Q
S
D
I
F
I
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
A249
L
S
V
N
K
H
R
A
Q
H
E
A
F
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
Y262
F
Q
A
S
R
E
N
Y
L
E
G
T
V
N
V
Honey Bee
Apis mellifera
XP_397381
980
112421
F237
F
I
A
S
K
E
N
F
L
E
G
F
V
N
V
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
Y263
F
S
V
S
R
E
N
Y
R
E
A
T
V
I
I
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
F389
F
K
A
S
R
E
N
F
R
E
G
Y
V
S
V
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
P249
L
R
V
N
R
Y
N
P
F
E
A
Y
V
G
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
P246
L
R
V
N
R
F
N
P
Y
E
A
Y
V
G
S
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
F285
I
Q
I
S
E
Y
N
F
L
E
G
S
V
S
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
100
93.3
N.A.
100
0
N.A.
93.3
86.6
13.3
0
N.A.
73.3
53.3
73.3
53.3
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
100
100
53.3
13.3
N.A.
86.6
73.3
73.3
73.3
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
40
N.A.
N.A.
40
33.3
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
46.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
59
0
0
0
0
12
0
0
59
12
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
6
0
0
0
6
0
0
0
% D
% Glu:
0
0
0
0
6
71
0
0
0
83
12
0
0
0
0
% E
% Phe:
59
0
0
0
0
6
0
18
6
0
0
6
12
6
0
% F
% Gly:
6
0
6
6
0
0
0
0
0
0
24
0
0
12
0
% G
% His:
0
0
0
0
0
12
0
0
0
6
0
0
0
0
0
% H
% Ile:
6
6
6
0
0
0
0
0
6
6
0
0
6
6
36
% I
% Lys:
0
6
0
0
24
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
24
6
0
0
0
0
0
0
59
0
0
0
0
0
6
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
6
0
24
0
0
83
0
0
0
0
0
0
12
0
% N
% Pro:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% P
% Gln:
0
12
0
0
0
0
0
0
12
6
0
0
0
0
0
% Q
% Arg:
0
53
0
0
71
0
12
0
12
0
0
0
0
0
12
% R
% Ser:
0
12
0
71
0
0
0
0
0
0
6
6
0
12
12
% S
% Thr:
0
0
0
0
0
0
6
0
0
0
0
53
0
0
0
% T
% Val:
0
0
30
0
0
0
0
0
0
0
0
0
83
12
36
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
42
0
% W
% Tyr:
6
0
0
0
0
12
0
53
6
0
0
18
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _