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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
37.27
Human Site:
Y65
Identified Species:
51.25
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
Y65
S
V
C
P
Q
P
H
Y
L
L
P
D
T
N
V
Chimpanzee
Pan troglodytes
XP_509678
958
109081
Y65
S
L
C
P
Q
P
H
Y
L
L
P
D
T
N
V
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
Y65
S
L
C
P
Q
P
H
Y
L
L
P
D
T
N
V
Dog
Lupus familis
XP_542610
1186
133310
Q96
T
P
R
V
R
L
G
Q
P
P
P
P
S
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
Y65
S
L
C
P
W
P
H
Y
L
L
P
D
T
N
V
Rat
Rattus norvegicus
Q5U2P0
1054
120741
Y58
L
S
A
E
V
T
H
Y
V
I
P
D
W
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
Y72
S
L
C
P
Q
P
H
Y
L
L
P
D
T
N
V
Chicken
Gallus gallus
XP_417016
963
109342
Y66
S
L
C
P
G
P
H
Y
L
L
P
D
T
N
L
Frog
Xenopus laevis
Q6GN11
1040
119148
Y54
L
S
E
E
L
T
H
Y
V
V
P
D
C
Q
V
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
Y55
L
S
R
D
V
T
H
Y
V
V
P
D
V
G
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
Y63
T
L
F
K
F
P
H
Y
L
V
L
D
T
N
V
Honey Bee
Apis mellifera
XP_397381
980
112421
Y48
F
R
I
Q
N
P
H
Y
L
L
I
D
T
N
I
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
A74
N
A
K
V
G
R
H
A
L
I
V
D
S
T
S
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
R182
A
L
N
Q
D
L
Y
R
K
V
Y
T
S
K
K
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
I54
L
T
A
T
A
S
T
I
L
I
L
D
T
N
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
I51
A
R
L
S
S
S
K
I
I
V
V
D
T
N
V
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
Y87
S
A
P
I
G
K
H
Y
V
V
L
D
T
N
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
93.3
93.3
6.6
N.A.
86.6
33.3
N.A.
93.3
80
33.3
33.3
N.A.
53.3
53.3
20
0
P-Site Similarity:
100
100
100
33.3
N.A.
93.3
46.6
N.A.
100
93.3
46.6
46.6
N.A.
73.3
60
40
33.3
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
33.3
N.A.
N.A.
26.6
46.6
N.A.
P-Site Similarity:
40
N.A.
N.A.
46.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
12
12
0
6
0
0
6
0
0
0
0
0
0
0
% A
% Cys:
0
0
36
0
0
0
0
0
0
0
0
0
6
0
0
% C
% Asp:
0
0
0
6
6
0
0
0
0
0
0
89
0
0
0
% D
% Glu:
0
0
6
12
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
6
0
6
0
6
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
18
0
6
0
0
0
0
0
0
6
0
% G
% His:
0
0
0
0
0
0
77
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
6
6
0
0
0
12
6
18
6
0
0
0
6
% I
% Lys:
0
0
6
6
0
6
6
0
6
0
0
0
0
12
6
% K
% Leu:
24
42
6
0
6
12
0
0
59
42
18
0
0
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
6
0
6
0
6
0
0
0
0
0
0
0
0
65
0
% N
% Pro:
0
6
6
36
0
48
0
0
6
6
59
6
0
6
0
% P
% Gln:
0
0
0
12
24
0
0
6
0
0
0
0
0
6
0
% Q
% Arg:
0
12
12
0
6
6
0
6
0
0
0
0
0
0
0
% R
% Ser:
42
18
0
6
6
12
0
0
0
0
0
0
18
0
6
% S
% Thr:
12
6
0
6
0
18
6
0
0
0
0
6
65
6
0
% T
% Val:
0
6
0
12
12
0
0
0
24
36
12
0
6
0
71
% V
% Trp:
0
0
0
0
6
0
0
0
0
0
0
0
6
0
0
% W
% Tyr:
0
0
0
0
0
0
6
71
0
0
6
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _