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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
33.03
Human Site:
Y801
Identified Species:
45.42
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
Y801
A
I
G
A
D
C
T
Y
P
E
L
T
D
K
H
Chimpanzee
Pan troglodytes
XP_509678
958
109081
Y801
A
I
G
A
D
C
T
Y
P
E
L
T
D
K
H
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
Y791
A
V
G
A
D
S
T
Y
P
E
L
T
D
K
H
Dog
Lupus familis
XP_542610
1186
133310
Y1029
A
I
G
A
D
C
T
Y
P
E
L
T
D
K
H
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
Y801
A
I
G
A
D
C
T
Y
P
E
L
T
D
K
H
Rat
Rattus norvegicus
Q5U2P0
1054
120741
D818
L
M
A
A
I
S
K
D
K
K
V
E
I
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
Y809
A
I
G
A
D
S
T
Y
P
E
L
T
D
K
H
Chicken
Gallus gallus
XP_417016
963
109342
Y804
A
I
G
A
D
S
T
Y
P
E
L
T
D
K
H
Frog
Xenopus laevis
Q6GN11
1040
119148
P811
L
A
A
V
N
K
G
P
K
D
H
L
L
G
N
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
P815
Q
L
E
K
D
E
S
P
S
K
A
L
A
C
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
Y810
S
I
G
A
D
S
T
Y
A
Q
L
L
D
R
K
Honey Bee
Apis mellifera
XP_397381
980
112421
Y778
C
I
G
A
D
A
T
Y
P
D
L
L
D
K
K
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
Q815
A
I
G
A
D
D
I
Q
S
G
L
L
N
Q
A
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
F1248
A
I
S
A
D
A
C
F
P
E
L
L
D
K
A
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
L795
S
D
V
I
V
H
R
L
L
A
A
S
I
G
I
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
L793
A
D
V
F
V
H
R
L
L
A
A
S
L
G
I
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
L858
D
V
V
A
H
R
Q
L
A
G
A
I
G
Y
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
86.6
100
N.A.
100
13.3
N.A.
93.3
93.3
0
6.6
N.A.
53.3
66.6
40
60
P-Site Similarity:
100
100
93.3
100
N.A.
100
33.3
N.A.
93.3
93.3
20
33.3
N.A.
73.3
73.3
53.3
66.6
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
59
6
12
77
0
12
0
0
12
12
24
0
6
0
12
% A
% Cys:
6
0
0
0
0
24
6
0
0
0
0
0
0
6
0
% C
% Asp:
6
12
0
0
71
6
0
6
0
12
0
0
59
0
0
% D
% Glu:
0
0
6
0
0
6
0
0
0
48
0
6
0
0
12
% E
% Phe:
0
0
0
6
0
0
0
6
0
0
0
0
0
0
0
% F
% Gly:
0
0
59
0
0
0
6
0
0
12
0
0
6
18
0
% G
% His:
0
0
0
0
6
12
0
0
0
0
6
0
0
0
42
% H
% Ile:
0
59
0
6
6
0
6
0
0
0
0
6
12
0
12
% I
% Lys:
0
0
0
6
0
6
6
0
12
12
0
0
0
59
12
% K
% Leu:
12
6
0
0
0
0
0
18
12
0
65
36
12
0
0
% L
% Met:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
6
0
0
0
0
0
0
0
6
0
12
% N
% Pro:
0
0
0
0
0
0
0
12
53
0
0
0
0
0
0
% P
% Gln:
6
0
0
0
0
0
6
6
0
6
0
0
0
6
0
% Q
% Arg:
0
0
0
0
0
6
12
0
0
0
0
0
0
6
0
% R
% Ser:
12
0
6
0
0
30
6
0
12
0
0
12
0
0
0
% S
% Thr:
0
0
0
0
0
0
53
0
0
0
0
42
0
0
0
% T
% Val:
0
12
18
6
12
0
0
0
0
0
6
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
53
0
0
0
0
0
6
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _