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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3
All Species:
26.97
Human Site:
Y887
Identified Species:
37.08
UniProt:
Q9Y2L1
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2L1
NP_001121698.1
958
109003
Y887
K
P
N
P
Q
L
I
Y
D
D
E
I
P
S
L
Chimpanzee
Pan troglodytes
XP_509678
958
109081
Y887
K
P
N
P
Q
L
I
Y
D
D
E
I
P
S
L
Rhesus Macaque
Macaca mulatta
XP_001083933
948
107719
Y877
K
P
N
P
R
L
I
Y
D
D
E
I
P
S
L
Dog
Lupus familis
XP_542610
1186
133310
Y1115
K
P
K
P
K
L
I
Y
D
D
E
V
P
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9CSH3
958
108819
Y887
K
P
K
P
R
L
A
Y
D
D
E
I
P
S
L
Rat
Rattus norvegicus
Q5U2P0
1054
120741
P915
G
L
V
I
S
C
G
P
E
G
S
S
E
W
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514554
966
109727
Y895
K
P
K
P
K
L
T
Y
N
D
E
V
P
S
L
Chicken
Gallus gallus
XP_417016
963
109342
Y890
K
P
T
P
K
L
D
Y
N
S
E
V
P
S
L
Frog
Xenopus laevis
Q6GN11
1040
119148
E903
G
L
V
L
A
C
E
E
D
G
Q
C
R
W
V
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
G907
G
Q
V
I
S
V
D
G
D
G
K
C
E
W
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651246
982
112164
F904
K
S
E
I
V
F
T
F
N
E
E
D
H
T
Q
Honey Bee
Apis mellifera
XP_397381
980
112421
Y863
E
S
N
V
V
F
I
Y
N
G
E
D
H
S
Q
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
V900
A
S
G
T
T
I
D
V
E
E
M
S
V
K
V
Sea Urchin
Strong. purpuratus
XP_787332
1412
160533
F1333
D
G
A
K
T
S
P
F
T
Y
D
D
E
E
P
Poplar Tree
Populus trichocarpa
XP_002303419
935
105261
E874
F
V
P
K
F
G
I
E
G
P
V
Y
L
T
M
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565418
933
104978
E872
F
V
P
K
Y
G
I
E
G
P
V
Y
L
T
G
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
G937
V
P
K
F
G
V
E
G
L
I
R
L
D
N
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
95.1
73.6
N.A.
91.1
35.2
N.A.
86.4
81
35.3
33.1
N.A.
55
55
46
36.7
Protein Similarity:
100
99.7
96.7
77.7
N.A.
96.4
52.1
N.A.
93.3
90.4
53.6
52.9
N.A.
72.7
72
63.3
50.8
P-Site Identity:
100
100
93.3
80
N.A.
80
0
N.A.
66.6
60
6.6
6.6
N.A.
13.3
33.3
0
0
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
6.6
N.A.
86.6
80
20
20
N.A.
40
46.6
26.6
13.3
Percent
Protein Identity:
46.8
N.A.
N.A.
47.9
43.3
N.A.
Protein Similarity:
66.3
N.A.
N.A.
65.7
61.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
20
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
6
0
6
0
6
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
12
0
0
0
0
0
12
0
0
0
% C
% Asp:
6
0
0
0
0
0
18
0
42
36
6
18
6
0
0
% D
% Glu:
6
0
6
0
0
0
12
18
12
12
53
0
18
6
0
% E
% Phe:
12
0
0
6
6
12
0
12
0
0
0
0
0
0
0
% F
% Gly:
18
6
6
0
6
12
6
12
12
24
0
0
0
0
6
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% H
% Ile:
0
0
0
18
0
6
42
0
0
6
0
24
0
0
0
% I
% Lys:
48
0
24
18
18
0
0
0
0
0
6
0
0
6
12
% K
% Leu:
0
12
0
6
0
42
0
0
6
0
0
6
12
0
48
% L
% Met:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
6
% M
% Asn:
0
0
24
0
0
0
0
0
24
0
0
0
0
6
0
% N
% Pro:
0
48
12
42
0
0
6
6
0
12
0
0
42
0
6
% P
% Gln:
0
6
0
0
12
0
0
0
0
0
6
0
0
0
12
% Q
% Arg:
0
0
0
0
12
0
0
0
0
0
6
0
6
0
0
% R
% Ser:
0
18
0
0
12
6
0
0
0
6
6
12
0
48
0
% S
% Thr:
0
0
6
6
12
0
12
0
6
0
0
0
0
18
0
% T
% Val:
6
12
18
6
12
12
0
6
0
0
12
18
6
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
18
0
% W
% Tyr:
0
0
0
0
6
0
0
48
0
6
0
12
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _