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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATP8A1 All Species: 19.09
Human Site: T294 Identified Species: 35
UniProt: Q9Y2Q0 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2Q0 NP_006086.1 1164 131369 T294 L S N V E R I T N V Q I L I L
Chimpanzee Pan troglodytes XP_001150768 1164 131363 T294 L S N V E R I T N V Q I L I L
Rhesus Macaque Macaca mulatta XP_001099138 1164 131392 T294 L S N V E R I T N V Q I L I L
Dog Lupus familis XP_849357 1158 131123 T294 L S N V E R I T N V Q I L I L
Cat Felis silvestris
Mouse Mus musculus P70704 1149 129748 N279 H D T K L M Q N S T S P P L K
Rat Rattus norvegicus XP_223390 1134 128100 Y269 W V H G I V V Y T G H D T K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518853 932 104820 G74 M S L V C S I G S V I W N Q R
Chicken Gallus gallus XP_420729 1223 137907 T353 M S N V E R I T N I Q I L I L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002666697 916 102033 D58 T G Y R K A E D E M S G T T S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001137649 1324 149578 E453 I V V Y S G Q E T K L M K N S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001200260 1167 132097 A280 L L L N S K A A P L K R S T V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9XIE6 1213 137734 I298 E K K L D K L I I T I F C V L
Baker's Yeast Sacchar. cerevisiae P39524 1355 153826 N445 T A V E K I I N R Q I I R L F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.8 96.9 N.A. 95.8 94.5 N.A. 74.4 88.5 N.A. 53.8 N.A. 50.9 N.A. N.A. 57.6
Protein Similarity: 100 100 100 98 N.A. 97.7 96.3 N.A. 76.9 92.4 N.A. 63.4 N.A. 65.4 N.A. N.A. 74.8
P-Site Identity: 100 100 100 100 N.A. 0 6.6 N.A. 26.6 86.6 N.A. 0 N.A. 0 N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 13.3 20 N.A. 40 100 N.A. 13.3 N.A. 13.3 N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. 39.2 39.9 N.A.
Protein Similarity: N.A. N.A. N.A. 58.6 57.6 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 8 8 8 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 8 0 0 8 0 0 8 0 0 0 8 0 0 0 % D
% Glu: 8 0 0 8 39 0 8 8 8 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % F
% Gly: 0 8 0 8 0 8 0 8 0 8 0 8 0 0 0 % G
% His: 8 0 8 0 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 8 0 0 0 8 8 54 8 8 8 24 47 0 39 0 % I
% Lys: 0 8 8 8 16 16 0 0 0 8 8 0 8 8 8 % K
% Leu: 39 8 16 8 8 0 8 0 0 8 8 0 39 16 54 % L
% Met: 16 0 0 0 0 8 0 0 0 8 0 8 0 0 0 % M
% Asn: 0 0 39 8 0 0 0 16 39 0 0 0 8 8 0 % N
% Pro: 0 0 0 0 0 0 0 0 8 0 0 8 8 0 0 % P
% Gln: 0 0 0 0 0 0 16 0 0 8 39 0 0 8 0 % Q
% Arg: 0 0 0 8 0 39 0 0 8 0 0 8 8 0 8 % R
% Ser: 0 47 0 0 16 8 0 0 16 0 16 0 8 0 16 % S
% Thr: 16 0 8 0 0 0 0 39 16 16 0 0 16 16 0 % T
% Val: 0 16 16 47 0 8 8 0 0 39 0 0 0 8 8 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % W
% Tyr: 0 0 8 8 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _