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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN22 All Species: 10.91
Human Site: S377 Identified Species: 24
UniProt: Q9Y2R2 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2R2 NP_057051.3 807 91705 S377 H P A K S S T S F D F L E L N
Chimpanzee Pan troglodytes XP_513663 807 91678 S377 H P A K S S T S F D F L E L N
Rhesus Macaque Macaca mulatta XP_001110241 807 91482 S377 H P A K S S T S F D F L E L N
Dog Lupus familis XP_540240 893 101055 Q462 L V L H P A G Q S S S F D L L
Cat Felis silvestris
Mouse Mus musculus P29352 802 89696 H373 A E E E L V L H S A K S S P S
Rat Rattus norvegicus NP_001099930 804 89584 H373 A K E E L V L H S K S S P S F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506530 800 89754 T367 Q R P S L V Q T Q E Q Y E L V
Chicken Gallus gallus XP_001235234 775 85980 P347 D V H Q H F P P L V R N E A P
Frog Xenopus laevis NP_001084841 660 74123 S232 V P L C I H C S A G C G R T G
Zebra Danio Brachydanio rerio NP_956963 570 64484 R142 M G R K K C E R Y F P L F G D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796904 967 106580 A396 Y A N C D V G A T S G D S G K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 95.5 71.1 N.A. 71.1 69.2 N.A. 57.1 50.8 36.3 34.3 N.A. N.A. N.A. N.A. 28.2
Protein Similarity: 100 99.8 97 77.9 N.A. 80.4 79.3 N.A. 68 64 50.9 49.9 N.A. N.A. N.A. N.A. 44.7
P-Site Identity: 100 100 100 6.6 N.A. 0 0 N.A. 13.3 6.6 13.3 13.3 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 100 20 N.A. 13.3 6.6 N.A. 26.6 13.3 13.3 26.6 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 10 28 0 0 10 0 10 10 10 0 0 0 10 0 % A
% Cys: 0 0 0 19 0 10 10 0 0 0 10 0 0 0 0 % C
% Asp: 10 0 0 0 10 0 0 0 0 28 0 10 10 0 10 % D
% Glu: 0 10 19 19 0 0 10 0 0 10 0 0 46 0 0 % E
% Phe: 0 0 0 0 0 10 0 0 28 10 28 10 10 0 10 % F
% Gly: 0 10 0 0 0 0 19 0 0 10 10 10 0 19 10 % G
% His: 28 0 10 10 10 10 0 19 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 10 0 37 10 0 0 0 0 10 10 0 0 0 10 % K
% Leu: 10 0 19 0 28 0 19 0 10 0 0 37 0 46 10 % L
% Met: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 28 % N
% Pro: 0 37 10 0 10 0 10 10 0 0 10 0 10 10 10 % P
% Gln: 10 0 0 10 0 0 10 10 10 0 10 0 0 0 0 % Q
% Arg: 0 10 10 0 0 0 0 10 0 0 10 0 10 0 0 % R
% Ser: 0 0 0 10 28 28 0 37 28 19 19 19 19 10 10 % S
% Thr: 0 0 0 0 0 0 28 10 10 0 0 0 0 10 0 % T
% Val: 10 19 0 0 0 37 0 0 0 10 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 0 10 0 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _