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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN22 All Species: 10
Human Site: S538 Identified Species: 22
UniProt: Q9Y2R2 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2R2 NP_057051.3 807 91705 S538 L V E N P Y F S S W P P S G T
Chimpanzee Pan troglodytes XP_513663 807 91678 S538 L V E N P Y F S S W P P S G T
Rhesus Macaque Macaca mulatta XP_001110241 807 91482 S538 L V E D P Y F S S W P P S G T
Dog Lupus familis XP_540240 893 101055 L623 S S E D P Y F L S L S P S S A
Cat Felis silvestris
Mouse Mus musculus P29352 802 89696 P534 Y T S L A E D P Y F S S S P P
Rat Rattus norvegicus NP_001099930 804 89584 E534 H L C M S L A E D P Y F S S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506530 800 89754 K528 S T Q K T G A K E L E M K D P
Chicken Gallus gallus XP_001235234 775 85980 C508 G P P G H R N C R Q C P Y H Y
Frog Xenopus laevis NP_001084841 660 74123 S393 K P V L H M Q S L N N P T D L
Zebra Danio Brachydanio rerio NP_956963 570 64484 N303 K L L E S P T N S E V T D G T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796904 967 106580 I557 K E A L R L P I K P T R N L E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 95.5 71.1 N.A. 71.1 69.2 N.A. 57.1 50.8 36.3 34.3 N.A. N.A. N.A. N.A. 28.2
Protein Similarity: 100 99.8 97 77.9 N.A. 80.4 79.3 N.A. 68 64 50.9 49.9 N.A. N.A. N.A. N.A. 44.7
P-Site Identity: 100 100 93.3 46.6 N.A. 6.6 6.6 N.A. 0 6.6 13.3 20 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 100 53.3 N.A. 13.3 20 N.A. 6.6 6.6 20 33.3 N.A. N.A. N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 10 0 19 0 0 0 0 0 0 0 10 % A
% Cys: 0 0 10 0 0 0 0 10 0 0 10 0 0 0 0 % C
% Asp: 0 0 0 19 0 0 10 0 10 0 0 0 10 19 0 % D
% Glu: 0 10 37 10 0 10 0 10 10 10 10 0 0 0 10 % E
% Phe: 0 0 0 0 0 0 37 0 0 10 0 10 0 0 0 % F
% Gly: 10 0 0 10 0 10 0 0 0 0 0 0 0 37 0 % G
% His: 10 0 0 0 19 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % I
% Lys: 28 0 0 10 0 0 0 10 10 0 0 0 10 0 0 % K
% Leu: 28 19 10 28 0 19 0 10 10 19 0 0 0 10 10 % L
% Met: 0 0 0 10 0 10 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 0 19 0 0 10 10 0 10 10 0 10 0 0 % N
% Pro: 0 19 10 0 37 10 10 10 0 19 28 55 0 10 19 % P
% Gln: 0 0 10 0 0 0 10 0 0 10 0 0 0 0 0 % Q
% Arg: 0 0 0 0 10 10 0 0 10 0 0 10 0 0 0 % R
% Ser: 19 10 10 0 19 0 0 37 46 0 19 10 55 19 10 % S
% Thr: 0 19 0 0 10 0 10 0 0 0 10 10 10 0 37 % T
% Val: 0 28 10 0 0 0 0 0 0 0 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 28 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 37 0 0 10 0 10 0 10 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _