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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN22 All Species: 13.94
Human Site: S668 Identified Species: 30.67
UniProt: Q9Y2R2 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2R2 NP_057051.3 807 91705 S668 E P K K F D D S V I L R P S K
Chimpanzee Pan troglodytes XP_513663 807 91678 S668 E P K K F D D S V R L R P S K
Rhesus Macaque Macaca mulatta XP_001110241 807 91482 S668 E P K K F D D S V R L R P S K
Dog Lupus familis XP_540240 893 101055 V754 L N T S D D S V R L R P T K S
Cat Felis silvestris
Mouse Mus musculus P29352 802 89696 D663 T S E M K S H D S V G F T P S
Rat Rattus norvegicus NP_001099930 804 89584 D665 T S E S Q S H D L V A F T S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506530 800 89754 S661 E S K A S D D S V R M R P S K
Chicken Gallus gallus XP_001235234 775 85980 N637 V P P S V T S N D S V R L R P
Frog Xenopus laevis NP_001084841 660 74123 S522 L E K G L S V S S G M C K N V
Zebra Danio Brachydanio rerio NP_956963 570 64484 Q432 E R L A V E I Q K V A L Q E G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796904 967 106580 S701 S R S S R K N S D E Y A Y V Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 95.5 71.1 N.A. 71.1 69.2 N.A. 57.1 50.8 36.3 34.3 N.A. N.A. N.A. N.A. 28.2
Protein Similarity: 100 99.8 97 77.9 N.A. 80.4 79.3 N.A. 68 64 50.9 49.9 N.A. N.A. N.A. N.A. 44.7
P-Site Identity: 100 93.3 93.3 6.6 N.A. 0 6.6 N.A. 66.6 13.3 13.3 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 93.3 93.3 13.3 N.A. 13.3 26.6 N.A. 73.3 26.6 26.6 20 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 19 0 0 0 0 0 0 19 10 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % C
% Asp: 0 0 0 0 10 46 37 19 19 0 0 0 0 0 0 % D
% Glu: 46 10 19 0 0 10 0 0 0 10 0 0 0 10 0 % E
% Phe: 0 0 0 0 28 0 0 0 0 0 0 19 0 0 0 % F
% Gly: 0 0 0 10 0 0 0 0 0 10 10 0 0 0 10 % G
% His: 0 0 0 0 0 0 19 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 10 0 0 10 0 0 0 0 0 % I
% Lys: 0 0 46 28 10 10 0 0 10 0 0 0 10 10 37 % K
% Leu: 19 0 10 0 10 0 0 0 10 10 28 10 10 0 0 % L
% Met: 0 0 0 10 0 0 0 0 0 0 19 0 0 0 0 % M
% Asn: 0 10 0 0 0 0 10 10 0 0 0 0 0 10 0 % N
% Pro: 0 37 10 0 0 0 0 0 0 0 0 10 37 10 10 % P
% Gln: 0 0 0 0 10 0 0 10 0 0 0 0 10 0 10 % Q
% Arg: 0 19 0 0 10 0 0 0 10 28 10 46 0 10 0 % R
% Ser: 10 28 10 37 10 28 19 55 19 10 0 0 0 46 28 % S
% Thr: 19 0 10 0 0 10 0 0 0 0 0 0 28 0 0 % T
% Val: 10 0 0 0 19 0 10 10 37 28 10 0 0 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 10 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _