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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CRYL1
All Species:
40.91
Human Site:
Y251
Identified Species:
75
UniProt:
Q9Y2S2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2S2
NP_057058.2
319
35419
Y251
N
A
E
G
M
L
S
Y
C
D
R
Y
S
E
G
Chimpanzee
Pan troglodytes
XP_001147059
297
33340
Y229
N
A
E
G
M
L
S
Y
C
D
R
Y
S
E
G
Rhesus Macaque
Macaca mulatta
XP_001086858
319
35329
Y251
N
A
E
G
M
L
S
Y
C
D
R
Y
S
E
G
Dog
Lupus familis
XP_543175
319
35414
Y251
N
A
E
G
M
L
N
Y
C
D
R
Y
R
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q99KP3
319
35190
Y251
N
A
E
G
V
I
S
Y
C
E
R
Y
S
E
G
Rat
Rattus norvegicus
Q811X6
319
35323
Y251
N
A
E
G
M
V
S
Y
C
D
R
Y
S
E
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518865
362
39761
Y294
N
S
Q
G
M
L
S
Y
C
E
Q
Y
S
E
G
Chicken
Gallus gallus
NP_001026001
281
31242
S235
F
G
P
V
P
E
F
S
G
E
I
E
Q
K
I
Frog
Xenopus laevis
NP_001091202
319
35836
Y251
N
A
E
G
F
K
S
Y
C
E
R
Y
G
E
G
Zebra Danio
Brachydanio rerio
NP_001038806
315
35077
D251
N
A
P
E
G
M
K
D
Y
L
Q
R
Y
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573114
315
34768
Y250
N
A
E
G
M
A
N
Y
F
E
R
Y
S
N
T
Honey Bee
Apis mellifera
NP_001129207
317
35842
Y250
N
A
E
G
M
K
K
Y
C
E
T
Y
K
N
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794386
316
34985
Y248
N
A
E
G
M
Q
S
Y
M
E
R
Y
T
Q
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93
98.1
82.7
N.A.
84
84.6
N.A.
65.4
58.6
61.7
55.1
N.A.
51
51.4
N.A.
51.4
Protein Similarity:
100
93
99.6
91.8
N.A.
93.7
93
N.A.
79
73.9
81.5
75.8
N.A.
70.2
70.5
N.A.
72.4
P-Site Identity:
100
100
100
86.6
N.A.
80
93.3
N.A.
73.3
0
73.3
13.3
N.A.
60
53.3
N.A.
60
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
100
13.3
80
26.6
N.A.
73.3
60
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
85
0
0
0
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
70
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
39
0
0
0
0
0
% D
% Glu:
0
0
77
8
0
8
0
0
0
54
0
8
0
62
8
% E
% Phe:
8
0
0
0
8
0
8
0
8
0
0
0
0
0
0
% F
% Gly:
0
8
0
85
8
0
0
0
8
0
0
0
8
0
62
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
8
% I
% Lys:
0
0
0
0
0
16
16
0
0
0
0
0
8
8
0
% K
% Leu:
0
0
0
0
0
39
0
0
0
8
0
0
0
0
0
% L
% Met:
0
0
0
0
70
8
0
0
8
0
0
0
0
0
0
% M
% Asn:
93
0
0
0
0
0
16
0
0
0
0
0
0
16
0
% N
% Pro:
0
0
16
0
8
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
8
0
0
0
0
16
0
8
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
70
8
8
0
0
% R
% Ser:
0
8
0
0
0
0
62
8
0
0
0
0
54
8
16
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
8
% T
% Val:
0
0
0
8
8
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
85
8
0
0
85
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _