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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KLHDC2 All Species: 22.73
Human Site: Y247 Identified Species: 50
UniProt: Q9Y2U9 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2U9 NP_055130.1 406 46099 Y247 A R M N D L H Y L N L D T W E
Chimpanzee Pan troglodytes XP_509933 307 34866 F160 Y K N K L I F F G G Y G Y L P
Rhesus Macaque Macaca mulatta XP_001098629 406 46128 Y247 A R M N D L H Y L N L D T W E
Dog Lupus familis XP_537436 406 46064 Y247 A R M N D L H Y L N L D T W E
Cat Felis silvestris
Mouse Mus musculus Q4G5Y1 406 45939 Y247 A R M N D L H Y L N L D T W E
Rat Rattus norvegicus Q3KRE6 406 45907 Y247 A R M N D L H Y L N L D T W E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514104 407 45986 Y248 S R M N D L H Y L N L D T W E
Chicken Gallus gallus Q5ZJ37 371 40041 T224 D L F C I D T T D M K W V K I
Frog Xenopus laevis Q5U580 411 46740 W250 V L G G G T S W T A Y S L E K
Zebra Danio Brachydanio rerio Q6GQN7 351 38328 H204 G T P P A Q R H G H V I T A V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002318573 398 44479 R235 S G Q K L P P R A G H S T V S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 74.6 99.5 98.7 N.A. 96.5 97 N.A. 88.9 22.6 21.6 21.6 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 75.1 99.7 99.5 N.A. 98.5 98.7 N.A. 94.8 36.4 35.7 37.9 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 100 100 N.A. 100 100 N.A. 93.3 0 0 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 100 100 N.A. 100 100 N.A. 100 0 13.3 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: 26.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 44.3 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 13.3 N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 46 0 0 0 10 0 0 0 10 10 0 0 0 10 0 % A
% Cys: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 55 10 0 0 10 0 0 55 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 55 % E
% Phe: 0 0 10 0 0 0 10 10 0 0 0 0 0 0 0 % F
% Gly: 10 10 10 10 10 0 0 0 19 19 0 10 0 0 0 % G
% His: 0 0 0 0 0 0 55 10 0 10 10 0 0 0 0 % H
% Ile: 0 0 0 0 10 10 0 0 0 0 0 10 0 0 10 % I
% Lys: 0 10 0 19 0 0 0 0 0 0 10 0 0 10 10 % K
% Leu: 0 19 0 0 19 55 0 0 55 0 55 0 10 10 0 % L
% Met: 0 0 55 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 0 0 10 55 0 0 0 0 0 55 0 0 0 0 0 % N
% Pro: 0 0 10 10 0 10 10 0 0 0 0 0 0 0 10 % P
% Gln: 0 0 10 0 0 10 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 55 0 0 0 0 10 10 0 0 0 0 0 0 0 % R
% Ser: 19 0 0 0 0 0 10 0 0 0 0 19 0 0 10 % S
% Thr: 0 10 0 0 0 10 10 10 10 0 0 0 73 0 0 % T
% Val: 10 0 0 0 0 0 0 0 0 0 10 0 10 10 10 % V
% Trp: 0 0 0 0 0 0 0 10 0 0 0 10 0 55 0 % W
% Tyr: 10 0 0 0 0 0 0 55 0 0 19 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _