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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COG6 All Species: 30.3
Human Site: S440 Identified Species: 51.28
UniProt: Q9Y2V7 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y2V7 NP_001138551.1 657 73279 S440 P P D L G P S S A L N Q T L M
Chimpanzee Pan troglodytes XP_509639 657 73244 S440 P P D L G P S S A L N Q T L M
Rhesus Macaque Macaca mulatta XP_001088372 657 73195 S440 P P D L G P S S A L N Q T L I
Dog Lupus familis XP_534488 657 73161 S440 P P D L G P S S A L N Q T L M
Cat Felis silvestris
Mouse Mus musculus Q8R3I3 657 73021 S440 P P D L G P S S A L S Q T L T
Rat Rattus norvegicus Q68FP9 657 72938 S440 P P D L G P S S A L S Q T L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512635 670 74494 A453 P P D L G P S A A L N Q T L T
Chicken Gallus gallus XP_417082 643 72198 S426 P P D L G P S S A L N Q T L N
Frog Xenopus laevis NP_001084743 648 72605 S431 P A D L G P S S A L N Q T L T
Zebra Danio Brachydanio rerio XP_001918856 305 34143 G92 F Y H H T I S G I M G T S V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V564 630 71187 Q417 G L A L E P P Q R D L V P P P
Honey Bee Apis mellifera XP_393779 627 71085 P414 G N D L V P A P S V S R L L S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784841 530 59722 Q317 G P T G S L T Q T L S L L R E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S4D8 713 79358 D477 P P D L R P P D F L T D A L E
Conservation
Percent
Protein Identity: 100 99.8 98.4 94.9 N.A. 91.1 92 N.A. 88.5 86.6 84 36.3 N.A. 40 44.9 N.A. 49.6
Protein Similarity: 100 99.8 99.2 97.8 N.A. 96 96.9 N.A. 92.6 92.8 92.6 40.9 N.A. 61.9 66.8 N.A. 65.7
P-Site Identity: 100 100 93.3 100 N.A. 86.6 86.6 N.A. 86.6 93.3 86.6 6.6 N.A. 13.3 26.6 N.A. 13.3
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 93.3 93.3 86.6 26.6 N.A. 13.3 60 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 27.6
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 47.4
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 46.6
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 0 0 8 8 65 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 79 0 0 0 0 8 0 8 0 8 0 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 15 % E
% Phe: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % F
% Gly: 22 0 0 8 65 0 0 8 0 0 8 0 0 0 0 % G
% His: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 8 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 8 0 86 0 8 0 0 0 79 8 8 15 79 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 22 % M
% Asn: 0 8 0 0 0 0 0 0 0 0 50 0 0 0 8 % N
% Pro: 72 72 0 0 0 86 15 8 0 0 0 0 8 8 8 % P
% Gln: 0 0 0 0 0 0 0 15 0 0 0 65 0 0 0 % Q
% Arg: 0 0 0 0 8 0 0 0 8 0 0 8 0 8 0 % R
% Ser: 0 0 0 0 8 0 72 58 8 0 29 0 8 0 15 % S
% Thr: 0 0 8 0 8 0 8 0 8 0 8 8 65 0 29 % T
% Val: 0 0 0 0 8 0 0 0 0 8 0 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _