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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMED5
All Species:
30.61
Human Site:
S162
Identified Species:
61.21
UniProt:
Q9Y3A6
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3A6
NP_057124.2
229
26005
S162
D
I
L
E
S
I
N
S
I
K
S
R
L
S
K
Chimpanzee
Pan troglodytes
XP_001154650
229
26004
S162
D
I
L
E
S
I
N
S
I
K
S
R
L
S
K
Rhesus Macaque
Macaca mulatta
XP_001103770
227
25115
T160
D
I
K
E
S
I
E
T
M
R
T
R
L
E
R
Dog
Lupus familis
XP_537072
472
52286
S405
D
I
L
E
S
I
N
S
I
K
A
R
L
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXE7
229
26153
S162
D
I
L
E
S
I
N
S
I
K
S
R
L
S
K
Rat
Rattus norvegicus
Q6AXN3
229
26117
S162
D
I
L
E
S
I
N
S
I
K
S
R
L
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508464
269
30032
N202
D
I
L
E
S
I
D
N
I
K
S
R
L
S
K
Chicken
Gallus gallus
NP_001007957
226
25656
S159
D
I
L
E
S
I
N
S
V
K
A
R
L
S
K
Frog
Xenopus laevis
NP_001090383
224
25760
S157
D
I
L
E
T
I
N
S
V
K
G
R
L
T
K
Zebra Danio
Brachydanio rerio
NP_956697
225
25592
N158
D
I
M
D
T
I
N
N
V
K
S
R
L
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_502288
234
26569
G159
E
F
H
R
R
A
N
G
I
K
N
N
L
N
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12450
207
23497
E140
I
A
N
N
A
I
E
E
I
D
R
N
L
N
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
55.4
46.8
N.A.
89.9
90.3
N.A.
62
83.4
68.5
66.8
N.A.
N.A.
N.A.
40.5
N.A.
Protein Similarity:
100
100
72
47.8
N.A.
94.7
95.1
N.A.
71.3
91.2
82
79.9
N.A.
N.A.
N.A.
61.1
N.A.
P-Site Identity:
100
100
46.6
93.3
N.A.
100
100
N.A.
86.6
86.6
73.3
60
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
100
100
80
100
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
N.A.
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
9
9
0
0
0
0
17
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
84
0
0
9
0
0
9
0
0
9
0
0
0
0
0
% D
% Glu:
9
0
0
75
0
0
17
9
0
0
0
0
0
9
0
% E
% Phe:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
9
0
0
9
0
0
9
0
% G
% His:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
84
0
0
0
92
0
0
67
0
0
0
0
0
0
% I
% Lys:
0
0
9
0
0
0
0
0
0
84
0
0
0
0
92
% K
% Leu:
0
0
67
0
0
0
0
0
0
0
0
0
100
0
0
% L
% Met:
0
0
9
0
0
0
0
0
9
0
0
0
0
0
0
% M
% Asn:
0
0
9
9
0
0
75
17
0
0
9
17
0
17
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
9
9
0
0
0
0
9
9
84
0
0
9
% R
% Ser:
0
0
0
0
67
0
0
59
0
0
50
0
0
59
0
% S
% Thr:
0
0
0
0
17
0
0
9
0
0
9
0
0
9
0
% T
% Val:
0
0
0
0
0
0
0
0
25
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _