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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMED5
All Species:
39.39
Human Site:
S219
Identified Species:
78.79
UniProt:
Q9Y3A6
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3A6
NP_057124.2
229
26005
S219
I
Q
V
Y
M
L
K
S
L
F
E
D
K
R
K
Chimpanzee
Pan troglodytes
XP_001154650
229
26004
S219
I
Q
V
Y
M
L
K
S
L
F
E
D
K
R
K
Rhesus Macaque
Macaca mulatta
XP_001103770
227
25115
R217
L
Q
V
C
T
L
K
R
F
F
Q
D
K
R
P
Dog
Lupus familis
XP_537072
472
52286
S462
I
Q
V
Y
M
L
K
S
L
F
E
D
K
R
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXE7
229
26153
S219
I
Q
V
Y
T
L
K
S
L
F
E
D
K
R
K
Rat
Rattus norvegicus
Q6AXN3
229
26117
S219
I
Q
V
Y
T
L
K
S
L
F
E
D
K
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508464
269
30032
S259
I
Q
V
Y
M
L
K
S
L
F
E
E
K
R
K
Chicken
Gallus gallus
NP_001007957
226
25656
S216
V
Q
V
Y
M
L
K
S
L
F
E
D
K
R
K
Frog
Xenopus laevis
NP_001090383
224
25760
S214
L
Q
V
Y
M
L
R
S
I
F
E
D
K
R
K
Zebra Danio
Brachydanio rerio
NP_956697
225
25592
S215
V
Q
V
Y
L
L
R
S
L
F
E
D
K
T
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_502288
234
26569
S216
V
Q
V
F
M
I
R
S
L
F
E
E
N
S
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12450
207
23497
F197
V
Q
A
L
I
I
Q
F
F
F
T
S
R
Q
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
55.4
46.8
N.A.
89.9
90.3
N.A.
62
83.4
68.5
66.8
N.A.
N.A.
N.A.
40.5
N.A.
Protein Similarity:
100
100
72
47.8
N.A.
94.7
95.1
N.A.
71.3
91.2
82
79.9
N.A.
N.A.
N.A.
61.1
N.A.
P-Site Identity:
100
100
53.3
100
N.A.
93.3
93.3
N.A.
93.3
93.3
80
73.3
N.A.
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
100
100
66.6
100
N.A.
93.3
93.3
N.A.
100
100
100
93.3
N.A.
N.A.
N.A.
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
75
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
84
17
0
0
0
% E
% Phe:
0
0
0
9
0
0
0
9
17
100
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
50
0
0
0
9
17
0
0
9
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
67
0
0
0
0
0
84
0
92
% K
% Leu:
17
0
0
9
9
84
0
0
75
0
0
0
0
0
0
% L
% Met:
0
0
0
0
59
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% P
% Gln:
0
100
0
0
0
0
9
0
0
0
9
0
0
9
0
% Q
% Arg:
0
0
0
0
0
0
25
9
0
0
0
0
9
75
0
% R
% Ser:
0
0
0
0
0
0
0
84
0
0
0
9
0
9
0
% S
% Thr:
0
0
0
0
25
0
0
0
0
0
9
0
0
9
0
% T
% Val:
34
0
92
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
75
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _