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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMED5
All Species:
33.03
Human Site:
T175
Identified Species:
66.06
UniProt:
Q9Y3A6
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3A6
NP_057124.2
229
26005
T175
S
K
S
G
H
I
Q
T
L
L
R
A
F
E
A
Chimpanzee
Pan troglodytes
XP_001154650
229
26004
T175
S
K
S
G
H
I
Q
T
L
L
R
A
F
E
A
Rhesus Macaque
Macaca mulatta
XP_001103770
227
25115
T173
E
R
S
I
Q
M
L
T
L
L
R
A
F
E
A
Dog
Lupus familis
XP_537072
472
52286
T418
S
K
S
G
H
I
Q
T
L
L
R
A
F
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXE7
229
26153
T175
S
K
S
G
H
I
Q
T
L
L
R
A
F
E
A
Rat
Rattus norvegicus
Q6AXN3
229
26117
T175
S
K
S
G
H
I
Q
T
L
L
R
A
F
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508464
269
30032
N215
S
K
S
V
H
L
Q
N
L
L
K
A
F
E
A
Chicken
Gallus gallus
NP_001007957
226
25656
T172
S
K
S
V
Q
I
Q
T
L
L
R
A
F
E
A
Frog
Xenopus laevis
NP_001090383
224
25760
T170
T
K
S
A
Q
I
Q
T
L
L
K
A
F
E
A
Zebra Danio
Brachydanio rerio
NP_956697
225
25592
T171
G
K
S
L
Q
I
Q
T
L
L
R
A
F
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_502288
234
26569
A172
N
K
V
E
Y
H
Q
A
L
L
R
A
H
E
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12450
207
23497
D153
N
K
I
T
K
T
M
D
Y
L
R
A
R
E
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
55.4
46.8
N.A.
89.9
90.3
N.A.
62
83.4
68.5
66.8
N.A.
N.A.
N.A.
40.5
N.A.
Protein Similarity:
100
100
72
47.8
N.A.
94.7
95.1
N.A.
71.3
91.2
82
79.9
N.A.
N.A.
N.A.
61.1
N.A.
P-Site Identity:
100
100
60
100
N.A.
100
100
N.A.
73.3
86.6
73.3
80
N.A.
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
100
100
73.3
100
N.A.
100
100
N.A.
86.6
86.6
86.6
80
N.A.
N.A.
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
0
9
0
0
0
100
0
0
92
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% D
% Glu:
9
0
0
9
0
0
0
0
0
0
0
0
0
100
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
84
0
0
% F
% Gly:
9
0
0
42
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
50
9
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
0
9
9
0
67
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
92
0
0
9
0
0
0
0
0
17
0
0
0
0
% K
% Leu:
0
0
0
9
0
9
9
0
92
100
0
0
0
0
0
% L
% Met:
0
0
0
0
0
9
9
0
0
0
0
0
0
0
0
% M
% Asn:
17
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
34
0
84
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
0
0
0
0
0
0
0
0
84
0
9
0
0
% R
% Ser:
59
0
84
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
9
0
0
9
0
9
0
75
0
0
0
0
0
0
0
% T
% Val:
0
0
9
17
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% W
% Tyr:
0
0
0
0
9
0
0
0
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _