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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HCN4
All Species:
9.7
Human Site:
Y527
Identified Species:
35.56
UniProt:
Q9Y3Q4
Number Species:
6
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Q4
NP_005468.1
1203
129042
Y527
L
D
S
S
R
R
Q
Y
Q
E
K
Y
K
Q
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001115891
777
86237
P127
F
K
E
E
N
S
P
P
W
I
V
F
N
V
L
Dog
Lupus familis
XP_535535
746
84568
A96
F
M
Q
R
Q
F
G
A
M
L
Q
A
G
V
N
Cat
Felis silvestris
Mouse
Mus musculus
O70507
1186
127396
Y527
L
D
S
S
R
R
Q
Y
Q
E
K
Y
K
Q
V
Rat
Rattus norvegicus
Q9JKA7
1198
128742
Y527
L
D
S
S
R
R
Q
Y
Q
E
K
Y
K
Q
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_425050
1188
129247
A501
S
Q
S
R
Q
F
R
A
Q
E
R
Y
K
Q
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_686078
1078
119210
Y428
T
W
G
Q
Q
Y
S
Y
A
L
F
K
A
M
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
48.8
57.9
N.A.
93.6
95.5
N.A.
N.A.
70.4
N.A.
61
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
N.A.
56.1
59.6
N.A.
94.9
96.3
N.A.
N.A.
77.5
N.A.
68.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
N.A.
0
0
N.A.
100
100
N.A.
N.A.
46.6
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
N.A.
13.3
13.3
N.A.
100
100
N.A.
N.A.
66.6
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
29
15
0
0
15
15
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
43
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
15
15
0
0
0
0
0
58
0
0
0
0
0
% E
% Phe:
29
0
0
0
0
29
0
0
0
0
15
15
0
0
0
% F
% Gly:
0
0
15
0
0
0
15
0
0
0
0
0
15
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% I
% Lys:
0
15
0
0
0
0
0
0
0
0
43
15
58
0
0
% K
% Leu:
43
0
0
0
0
0
0
0
0
29
0
0
0
0
15
% L
% Met:
0
15
0
0
0
0
0
0
15
0
0
0
0
15
0
% M
% Asn:
0
0
0
0
15
0
0
0
0
0
0
0
15
0
15
% N
% Pro:
0
0
0
0
0
0
15
15
0
0
0
0
0
0
0
% P
% Gln:
0
15
15
15
43
0
43
0
58
0
15
0
0
58
0
% Q
% Arg:
0
0
0
29
43
43
15
0
0
0
15
0
0
0
0
% R
% Ser:
15
0
58
43
0
15
15
0
0
0
0
0
0
0
15
% S
% Thr:
15
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
15
0
0
29
58
% V
% Trp:
0
15
0
0
0
0
0
0
15
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
15
0
58
0
0
0
58
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _