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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SAMHD1 All Species: 8.79
Human Site: S475 Identified Species: 16.11
UniProt: Q9Y3Z3 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y3Z3 NP_056289.2 626 72201 S475 I K R E D Y E S L P K E V A S
Chimpanzee Pan troglodytes XP_514624 382 43769 L244 S V M M F E H L I N S N G I K
Rhesus Macaque Macaca mulatta XP_001097562 728 83194 S577 I K K E D Y E S L P K E V A A
Dog Lupus familis XP_542986 665 76981 S513 I E R E N Y K S L P E E I A R
Cat Felis silvestris
Mouse Mus musculus Q60710 627 72632 L487 R K E E Y E R L P Q E V A K A
Rat Rattus norvegicus XP_230789 677 77635 L537 K K A E Y D K L A Q E V A N A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZJL9 614 70202 G466 I P K D E Y D G L A G D I A N
Frog Xenopus laevis Q6INN8 632 72730 K480 I E P D K Y D K L P A D L A S
Zebra Danio Brachydanio rerio Q502K2 622 71649 D455 V S Q E K L L D W A K E L A R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09374 587 66474 N428 T Q L K G N C N N Q T G A A E
Sea Urchin Strong. purpuratus XP_784786 594 68895 Q456 P E L K I R K Q I C K A V S V
Poplar Tree Populus trichocarpa XP_002312899 477 54770 N339 I R R I R T R N L Y Q F C N E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568580 473 54655 R335 L I L R V R R R Q L Y Q F C N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 58.9 79.5 73.5 N.A. 73.3 65.8 N.A. N.A. 60 61.8 60.8 N.A. N.A. N.A. 22.5 46.8
Protein Similarity: 100 60.2 82.4 83.6 N.A. 83.2 76.2 N.A. N.A. 74.9 75.3 74.1 N.A. N.A. N.A. 40.8 64.2
P-Site Identity: 100 0 86.6 60 N.A. 13.3 13.3 N.A. N.A. 26.6 40 26.6 N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: 100 6.6 100 93.3 N.A. 26.6 33.3 N.A. N.A. 73.3 73.3 46.6 N.A. N.A. N.A. 26.6 46.6
Percent
Protein Identity: 28.2 N.A. N.A. 30.5 N.A. N.A.
Protein Similarity: 45 N.A. N.A. 47.2 N.A. N.A.
P-Site Identity: 20 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 40 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 0 8 16 8 8 24 54 24 % A
% Cys: 0 0 0 0 0 0 8 0 0 8 0 0 8 8 0 % C
% Asp: 0 0 0 16 16 8 16 8 0 0 0 16 0 0 0 % D
% Glu: 0 24 8 47 8 16 16 0 0 0 24 31 0 0 16 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 8 8 0 0 % F
% Gly: 0 0 0 0 8 0 0 8 0 0 8 8 8 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 47 8 0 8 8 0 0 0 16 0 0 0 16 8 0 % I
% Lys: 8 31 16 16 16 0 24 8 0 0 31 0 0 8 8 % K
% Leu: 8 0 24 0 0 8 8 24 47 8 0 0 16 0 0 % L
% Met: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 8 0 16 8 8 0 8 0 16 16 % N
% Pro: 8 8 8 0 0 0 0 0 8 31 0 0 0 0 0 % P
% Gln: 0 8 8 0 0 0 0 8 8 24 8 8 0 0 0 % Q
% Arg: 8 8 24 8 8 16 24 8 0 0 0 0 0 0 16 % R
% Ser: 8 8 0 0 0 0 0 24 0 0 8 0 0 8 16 % S
% Thr: 8 0 0 0 0 8 0 0 0 0 8 0 0 0 0 % T
% Val: 8 8 0 0 8 0 0 0 0 0 0 16 24 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 16 39 0 0 0 8 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _