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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
16.67
Human Site:
S538
Identified Species:
30.56
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
S538
R
I
T
K
N
Q
V
S
Q
L
L
P
E
K
F
Chimpanzee
Pan troglodytes
XP_514624
382
43769
L297
R
P
E
N
K
S
F
L
Y
E
I
V
S
N
K
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
S640
R
I
T
K
N
Q
V
S
R
L
L
P
E
K
F
Dog
Lupus familis
XP_542986
665
76981
S577
M
I
T
K
D
Q
V
S
E
F
L
P
E
R
F
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
A540
C
K
S
N
S
K
Q
A
V
R
I
N
K
E
Q
Rat
Rattus norvegicus
XP_230789
677
77635
A590
C
K
S
D
S
R
Q
A
V
T
I
T
K
D
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
A521
C
K
A
D
P
S
K
A
I
K
V
S
K
E
Q
Frog
Xenopus laevis
Q6INN8
632
72730
S544
K
I
R
R
D
Q
V
S
Q
L
L
P
E
K
F
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
S517
K
I
H
K
K
Q
V
S
K
L
L
P
E
R
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
K500
K
P
S
E
H
E
G
K
Q
V
V
G
F
Y
P
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
K509
N
D
P
N
R
T
F
K
I
P
K
G
R
V
S
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
L392
V
S
N
V
R
I
D
L
T
R
G
R
H
N
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
A388
T
N
V
K
I
D
L
A
R
G
R
E
N
P
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
6.6
93.3
66.6
N.A.
0
0
N.A.
N.A.
0
73.3
66.6
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
13.3
100
86.6
N.A.
46.6
40
N.A.
N.A.
26.6
93.3
86.6
N.A.
N.A.
N.A.
53.3
0
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
0
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
31
0
0
0
0
0
0
0
% A
% Cys:
24
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
16
16
8
8
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
8
8
0
8
0
0
8
8
0
8
39
16
0
% E
% Phe:
0
0
0
0
0
0
16
0
0
8
0
0
8
0
39
% F
% Gly:
0
0
0
0
0
0
8
0
0
8
8
16
0
0
0
% G
% His:
0
0
8
0
8
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
39
0
0
8
8
0
0
16
0
24
0
0
0
0
% I
% Lys:
24
24
0
39
16
8
8
16
8
8
8
0
24
24
8
% K
% Leu:
0
0
0
0
0
0
8
16
0
31
39
0
0
0
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
8
24
16
0
0
0
0
0
0
8
8
16
0
% N
% Pro:
0
16
8
0
8
0
0
0
0
8
0
39
0
8
16
% P
% Gln:
0
0
0
0
0
39
16
0
24
0
0
0
0
0
24
% Q
% Arg:
24
0
8
8
16
8
0
0
16
16
8
8
8
16
0
% R
% Ser:
0
8
24
0
16
16
0
39
0
0
0
8
8
0
8
% S
% Thr:
8
0
24
0
0
8
0
0
8
8
0
8
0
0
0
% T
% Val:
8
0
8
8
0
0
39
0
16
8
16
8
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _