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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
36.67
Human Site:
Y374
Identified Species:
67.22
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
Y374
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
Chimpanzee
Pan troglodytes
XP_514624
382
43769
L144
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
Y476
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
Dog
Lupus familis
XP_542986
665
76981
Y412
N
T
L
H
R
R
A
Y
Q
H
K
V
G
N
I
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
Y386
N
C
L
H
R
R
A
Y
Q
H
K
I
S
N
L
Rat
Rattus norvegicus
XP_230789
677
77635
Y436
N
C
L
H
R
R
A
Y
Q
H
K
I
G
N
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
Y365
N
C
L
H
R
R
A
Y
Q
H
K
V
G
N
I
Frog
Xenopus laevis
Q6INN8
632
72730
Y379
N
C
L
H
R
R
A
Y
Q
H
K
V
G
N
I
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
Y354
N
C
L
H
R
R
A
Y
Q
H
K
V
G
N
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
Y325
Q
E
L
H
S
K
V
Y
Q
H
K
A
V
R
F
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
Y351
N
T
L
H
R
R
A
Y
Q
H
K
V
N
K
I
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
M239
F
Q
R
L
M
Q
T
M
R
V
M
G
D
E
I
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
T235
Q
F
Q
R
L
T
E
T
M
R
V
L
D
N
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
0
100
93.3
N.A.
73.3
80
N.A.
N.A.
93.3
93.3
93.3
N.A.
N.A.
N.A.
40
80
P-Site Similarity:
100
33.3
100
100
N.A.
86.6
93.3
N.A.
N.A.
93.3
93.3
93.3
N.A.
N.A.
N.A.
46.6
86.6
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
70
0
0
0
0
8
0
0
0
% A
% Cys:
0
39
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
0
0
16
0
0
% D
% Glu:
0
8
0
0
0
0
8
0
0
0
0
0
0
8
8
% E
% Phe:
8
8
0
0
8
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
54
0
8
% G
% His:
0
0
0
77
0
0
0
0
0
77
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
16
0
0
62
% I
% Lys:
0
0
0
0
0
8
0
0
0
0
77
8
0
8
0
% K
% Leu:
0
0
77
8
8
0
0
8
0
0
0
8
0
8
16
% L
% Met:
0
0
0
0
8
0
0
8
8
0
8
0
0
0
0
% M
% Asn:
70
0
0
0
0
0
0
0
0
0
0
0
8
70
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
16
8
8
8
0
16
0
0
77
0
0
0
8
0
0
% Q
% Arg:
0
0
8
8
70
70
8
0
16
8
0
0
0
8
0
% R
% Ser:
0
16
0
0
8
0
0
0
0
0
0
0
8
0
0
% S
% Thr:
0
24
0
0
0
8
8
8
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
8
0
0
8
8
54
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
77
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _