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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
17.88
Human Site:
Y419
Identified Species:
32.78
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
Y419
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
Chimpanzee
Pan troglodytes
XP_514624
382
43769
L189
L
G
E
K
Q
P
E
L
Q
I
S
E
R
D
I
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
Y521
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
Dog
Lupus familis
XP_542986
665
76981
F457
A
I
D
D
M
E
A
F
T
K
L
T
D
N
I
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
F431
A
I
D
D
M
E
A
F
T
K
L
T
D
N
I
Rat
Rattus norvegicus
XP_230789
677
77635
F481
A
I
H
D
M
E
A
F
S
K
L
T
D
N
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
Y410
A
M
E
D
M
E
A
Y
T
K
L
T
D
N
I
Frog
Xenopus laevis
Q6INN8
632
72730
Y424
S
V
D
D
M
V
A
Y
T
K
L
T
D
N
I
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
Y399
A
I
E
D
M
E
A
Y
S
K
L
T
D
H
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
F370
V
T
E
D
V
D
A
F
L
K
T
T
D
Y
V
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
D396
T
M
S
E
S
L
D
D
M
H
A
Y
T
H
M
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
V284
K
A
I
E
L
M
I
V
D
A
L
V
E
A
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
I280
V
K
A
I
E
L
M
I
V
D
A
M
V
K
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
6.6
100
93.3
N.A.
93.3
80
N.A.
N.A.
86.6
80
80
N.A.
N.A.
N.A.
33.3
0
P-Site Similarity:
100
20
100
100
N.A.
100
93.3
N.A.
N.A.
100
93.3
100
N.A.
N.A.
N.A.
66.6
26.6
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
54
8
8
0
0
0
70
0
0
8
16
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
39
70
0
8
8
8
8
8
0
0
70
8
0
% D
% Glu:
0
0
31
16
8
54
8
0
0
0
0
8
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
31
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
8
0
0
0
16
0
% H
% Ile:
0
47
8
8
0
0
8
8
0
8
0
0
0
0
70
% I
% Lys:
8
8
0
8
0
0
0
0
0
70
0
0
0
8
0
% K
% Leu:
8
0
0
0
8
16
0
8
8
0
70
0
0
0
0
% L
% Met:
0
16
0
0
62
8
8
0
8
0
0
8
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
54
8
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
8
0
8
0
8
0
0
0
16
0
8
0
0
0
0
% S
% Thr:
8
8
0
0
0
0
0
0
47
0
8
70
8
0
0
% T
% Val:
16
8
0
0
8
8
0
8
8
0
0
8
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
39
0
0
0
8
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _