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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
16.97
Human Site:
Y473
Identified Species:
31.11
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
Y473
I
K
I
K
R
E
D
Y
E
S
L
P
K
E
V
Chimpanzee
Pan troglodytes
XP_514624
382
43769
E242
Q
G
S
V
M
M
F
E
H
L
I
N
S
N
G
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
Y575
V
K
I
K
K
E
D
Y
E
S
L
P
K
E
V
Dog
Lupus familis
XP_542986
665
76981
Y511
I
R
I
E
R
E
N
Y
K
S
L
P
E
E
I
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
E485
K
I
R
K
E
E
Y
E
R
L
P
Q
E
V
A
Rat
Rattus norvegicus
XP_230789
677
77635
D535
K
I
K
K
A
E
Y
D
K
L
A
Q
E
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
Y464
N
E
I
P
K
D
E
Y
D
G
L
A
G
D
I
Frog
Xenopus laevis
Q6INN8
632
72730
Y478
S
R
I
E
P
D
K
Y
D
K
L
P
A
D
L
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
L453
V
D
V
S
Q
E
K
L
L
D
W
A
K
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
N426
N
A
T
Q
L
K
G
N
C
N
N
Q
T
G
A
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
R454
L
D
P
E
L
K
I
R
K
Q
I
C
K
A
V
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
T337
N
L
I
R
R
I
R
T
R
N
L
Y
Q
F
C
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
R333
K
E
L
I
L
R
V
R
R
R
Q
L
Y
Q
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
0
86.6
60
N.A.
13.3
13.3
N.A.
N.A.
20
26.6
20
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
100
6.6
100
100
N.A.
20
26.6
N.A.
N.A.
66.6
66.6
46.6
N.A.
N.A.
N.A.
20
46.6
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
20
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
40
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
0
0
0
0
8
16
8
8
24
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
8
% C
% Asp:
0
16
0
0
0
16
16
8
16
8
0
0
0
16
0
% D
% Glu:
0
16
0
24
8
47
8
16
16
0
0
0
24
31
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
8
% F
% Gly:
0
8
0
0
0
0
8
0
0
8
0
0
8
8
8
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
16
16
47
8
0
8
8
0
0
0
16
0
0
0
16
% I
% Lys:
24
16
8
31
16
16
16
0
24
8
0
0
31
0
0
% K
% Leu:
8
8
8
0
24
0
0
8
8
24
47
8
0
0
16
% L
% Met:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
24
0
0
0
0
0
8
8
0
16
8
8
0
8
0
% N
% Pro:
0
0
8
8
8
0
0
0
0
0
8
31
0
0
0
% P
% Gln:
8
0
0
8
8
0
0
0
0
8
8
24
8
8
0
% Q
% Arg:
0
16
8
8
24
8
8
16
24
8
0
0
0
0
0
% R
% Ser:
8
0
8
8
0
0
0
0
0
24
0
0
8
0
0
% S
% Thr:
0
0
8
0
0
0
0
8
0
0
0
0
8
0
0
% T
% Val:
16
0
8
8
0
0
8
0
0
0
0
0
0
16
24
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
16
39
0
0
0
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _