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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DYRK1B All Species: 36.06
Human Site: S314 Identified Species: 79.33
UniProt: Q9Y463 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y463 NP_004705.1 629 69198 S314 H T G E P L F S G S N E V D Q
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001089972 629 69208 S314 H T G E P L F S G S N E V D Q
Dog Lupus familis XP_853246 689 75066 S374 H T G E P L F S G S N E V D Q
Cat Felis silvestris
Mouse Mus musculus Q9Z188 629 69160 S314 H T G E P L F S G S N E V D Q
Rat Rattus norvegicus Q63470 763 85522 S362 H T G E P L F S G A N E V D Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509695 797 89233 S396 H T G E P L F S G A N E V D Q
Chicken Gallus gallus Q5ZIU3 526 59419 E227 S H I C M T F E L L S M N L Y
Frog Xenopus laevis Q2TAE3 750 84138 S354 H T G E P L F S G A N E V D Q
Zebra Danio Brachydanio rerio XP_684056 681 76846 S314 H T G E P L F S G S N E V D Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49657 908 95884 S367 H T G E P L F S G C N E V D Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51566 467 54180 R168 D V L Q R L T R H D V G G S R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.5 90.2 N.A. 97.3 54.7 N.A. 52.7 32.1 55.4 64.7 N.A. 45.1 N.A. N.A. N.A.
Protein Similarity: 100 N.A. 99.6 90.5 N.A. 97.9 64.4 N.A. 61.7 46 65.3 72.2 N.A. 54.1 N.A. N.A. N.A.
P-Site Identity: 100 N.A. 100 100 N.A. 100 93.3 N.A. 93.3 6.6 93.3 100 N.A. 93.3 N.A. N.A. N.A.
P-Site Similarity: 100 N.A. 100 100 N.A. 100 100 N.A. 100 13.3 100 100 N.A. 93.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.1 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 36 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 28 0 0 0 0 0 % A
% Cys: 0 0 0 10 0 0 0 0 0 10 0 0 0 0 0 % C
% Asp: 10 0 0 0 0 0 0 0 0 10 0 0 0 82 0 % D
% Glu: 0 0 0 82 0 0 0 10 0 0 0 82 0 0 0 % E
% Phe: 0 0 0 0 0 0 91 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 82 0 0 0 0 0 82 0 0 10 10 0 0 % G
% His: 82 10 0 0 0 0 0 0 10 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 10 0 0 91 0 0 10 10 0 0 0 10 0 % L
% Met: 0 0 0 0 10 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 82 0 10 0 0 % N
% Pro: 0 0 0 0 82 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 82 % Q
% Arg: 0 0 0 0 10 0 0 10 0 0 0 0 0 0 10 % R
% Ser: 10 0 0 0 0 0 0 82 0 46 10 0 0 10 0 % S
% Thr: 0 82 0 0 0 10 10 0 0 0 0 0 0 0 0 % T
% Val: 0 10 0 0 0 0 0 0 0 0 10 0 82 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _