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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK1B
All Species:
15.45
Human Site:
S504
Identified Species:
34
UniProt:
Q9Y463
Number Species:
10
Phosphosite Substitution
Charge Score:
0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y463
NP_004705.1
629
69198
S504
I
T
D
C
E
M
N
S
P
Q
V
P
P
S
Q
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001089972
629
69208
S504
I
T
D
C
E
M
N
S
P
Q
V
P
P
S
Q
Dog
Lupus familis
XP_853246
689
75066
S564
I
T
D
C
E
M
N
S
P
Q
V
P
P
S
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z188
629
69160
S504
I
T
D
C
E
M
N
S
P
Q
V
L
P
S
Q
Rat
Rattus norvegicus
Q63470
763
85522
E552
A
V
Q
A
M
D
C
E
T
H
S
P
Q
V
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509695
797
89233
E586
A
V
Q
A
M
D
C
E
T
H
S
P
Q
V
R
Chicken
Gallus gallus
Q5ZIU3
526
59419
L402
L
S
D
G
S
I
I
L
N
G
G
R
S
R
R
Frog
Xenopus laevis
Q2TAE3
750
84138
T544
A
V
A
M
D
C
E
T
H
S
P
Q
V
R
Q
Zebra Danio
Brachydanio rerio
XP_684056
681
76846
S511
M
Q
S
P
Q
A
P
S
Q
Q
Q
L
R
I
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49657
908
95884
G557
A
T
A
A
G
S
S
G
S
G
S
S
V
G
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
E343
E
A
L
F
Q
T
H
E
N
L
E
H
L
A
M
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.5
90.2
N.A.
97.3
54.7
N.A.
52.7
32.1
55.4
64.7
N.A.
45.1
N.A.
N.A.
N.A.
Protein Similarity:
100
N.A.
99.6
90.5
N.A.
97.9
64.4
N.A.
61.7
46
65.3
72.2
N.A.
54.1
N.A.
N.A.
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
93.3
6.6
N.A.
6.6
6.6
6.6
13.3
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
93.3
13.3
N.A.
13.3
33.3
20
26.6
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
37
10
19
28
0
10
0
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
0
37
0
10
19
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
46
0
10
19
0
0
0
0
0
0
0
0
0
% D
% Glu:
10
0
0
0
37
0
10
28
0
0
10
0
0
0
0
% E
% Phe:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
10
0
0
10
0
19
10
0
0
10
10
% G
% His:
0
0
0
0
0
0
10
0
10
19
0
10
0
0
0
% H
% Ile:
37
0
0
0
0
10
10
0
0
0
0
0
0
10
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
10
0
0
0
0
10
0
10
0
19
10
0
0
% L
% Met:
10
0
0
10
19
37
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
37
0
19
0
0
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
10
0
37
0
10
46
37
0
0
% P
% Gln:
0
10
19
0
19
0
0
0
10
46
10
10
19
0
46
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
10
19
28
% R
% Ser:
0
10
10
0
10
10
10
46
10
10
28
10
10
37
0
% S
% Thr:
0
46
0
0
0
10
0
10
19
0
0
0
0
0
0
% T
% Val:
0
28
0
0
0
0
0
0
0
0
37
0
19
19
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _