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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK1B
All Species:
35.15
Human Site:
Y172
Identified Species:
77.33
UniProt:
Q9Y463
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y463
NP_004705.1
629
69198
Y172
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001089972
629
69208
Y172
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
Dog
Lupus familis
XP_853246
689
75066
Y232
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z188
629
69160
Y172
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
Rat
Rattus norvegicus
Q63470
763
85522
Y220
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509695
797
89233
Y254
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
Chicken
Gallus gallus
Q5ZIU3
526
59419
E96
M
Q
K
L
T
T
F
E
H
N
E
I
F
G
Y
Frog
Xenopus laevis
Q2TAE3
750
84138
Y212
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
Zebra Danio
Brachydanio rerio
XP_684056
681
76846
Y172
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49657
908
95884
Y225
A
D
A
E
N
K
Y
Y
I
V
K
L
K
R
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
K36
I
V
D
K
R
P
R
K
R
P
R
L
T
W
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.5
90.2
N.A.
97.3
54.7
N.A.
52.7
32.1
55.4
64.7
N.A.
45.1
N.A.
N.A.
N.A.
Protein Similarity:
100
N.A.
99.6
90.5
N.A.
97.9
64.4
N.A.
61.7
46
65.3
72.2
N.A.
54.1
N.A.
N.A.
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
100
N.A.
100
0
100
100
N.A.
73.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
100
20
100
100
N.A.
73.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
82
10
0
0
0
0
0
0
0
0
0
0
0
10
% D
% Glu:
0
0
0
82
0
0
0
10
0
0
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% G
% His:
73
0
0
0
0
0
0
0
10
0
73
0
0
0
82
% H
% Ile:
10
0
0
0
0
0
0
0
82
0
0
10
0
0
0
% I
% Lys:
0
0
10
10
0
82
0
10
0
0
10
0
82
0
0
% K
% Leu:
0
0
0
10
0
0
0
0
0
0
0
91
0
0
0
% L
% Met:
10
0
0
0
73
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
10
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% P
% Gln:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
10
0
10
0
10
0
10
0
0
82
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
73
0
10
10
0
0
0
0
0
0
10
0
0
% T
% Val:
0
10
0
0
0
0
0
0
0
82
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% W
% Tyr:
0
0
0
0
0
0
82
82
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _