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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK1B
All Species:
34.55
Human Site:
Y401
Identified Species:
76
UniProt:
Q9Y463
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y463
NP_004705.1
629
69198
Y401
P
G
H
S
P
A
D
Y
L
R
F
Q
D
L
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001089972
629
69208
Y401
P
G
H
S
P
A
D
Y
L
R
F
Q
D
L
V
Dog
Lupus familis
XP_853246
689
75066
Y461
P
G
H
S
P
A
D
Y
L
R
F
Q
D
L
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z188
629
69160
Y401
P
G
H
S
P
A
D
Y
L
R
F
Q
D
L
V
Rat
Rattus norvegicus
Q63470
763
85522
Y449
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509695
797
89233
Y483
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
Chicken
Gallus gallus
Q5ZIU3
526
59419
Y299
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Frog
Xenopus laevis
Q2TAE3
750
84138
Y441
S
G
H
T
V
A
D
Y
L
K
F
K
D
V
I
Zebra Danio
Brachydanio rerio
XP_684056
681
76846
Y408
Q
G
H
A
P
C
D
Y
L
K
F
K
D
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49657
908
95884
Y454
P
G
H
S
V
S
D
Y
L
K
F
K
D
L
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
D240
D
L
R
L
I
H
T
D
L
K
P
E
N
I
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.5
90.2
N.A.
97.3
54.7
N.A.
52.7
32.1
55.4
64.7
N.A.
45.1
N.A.
N.A.
N.A.
Protein Similarity:
100
N.A.
99.6
90.5
N.A.
97.9
64.4
N.A.
61.7
46
65.3
72.2
N.A.
54.1
N.A.
N.A.
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
60
N.A.
60
6.6
53.3
60
N.A.
66.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
86.6
N.A.
86.6
20
86.6
86.6
N.A.
93.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
64
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
10
10
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
0
0
0
82
10
0
0
0
0
82
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
82
0
0
0
0
% F
% Gly:
0
82
0
10
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
82
0
0
10
0
0
0
10
0
0
0
0
0
% H
% Ile:
10
0
0
0
10
0
0
0
0
0
0
0
0
10
46
% I
% Lys:
0
0
0
0
0
0
0
0
0
55
0
46
0
0
0
% K
% Leu:
0
10
0
10
0
0
0
0
91
0
0
0
0
73
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
46
0
0
0
46
0
0
0
0
0
10
0
0
0
0
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
10
37
0
0
0
% Q
% Arg:
0
0
10
0
0
0
0
0
0
37
0
10
0
0
0
% R
% Ser:
28
0
0
46
10
19
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
28
0
0
10
0
0
0
0
0
0
0
10
% T
% Val:
0
0
0
0
37
0
0
0
0
0
0
0
10
10
37
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
91
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _