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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NR2E1 All Species: 23.94
Human Site: S377 Identified Species: 47.88
UniProt: Q9Y466 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y466 NP_003260.1 385 42589 S377 V P I T R L L S D M Y K S S D
Chimpanzee Pan troglodytes XP_001175025 402 43746 L395 G N T P M E K L L C D M F K N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532253 385 42541 S377 V P I T R L L S D M Y K S S D
Cat Felis silvestris
Mouse Mus musculus Q64104 385 42601 S377 V P I T R L L S D M Y K S S D
Rat Rattus norvegicus O09018 414 45583 R397 T P I E T L I R D M L L S G S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q91379 385 42465 S377 V P I T R L L S D M Y K S S D
Frog Xenopus laevis P70052 386 42956 S378 V P I T R V L S D M Y K S S D
Zebra Danio Brachydanio rerio Q06725 411 45463 R394 T P I E T L I R D M L L S G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P18102 452 50531 S444 I T I V R L I S D M Y S Q R K
Honey Bee Apis mellifera XP_001121187 418 45540 R409 I G I I P I E R I I C D M Y K
Nematode Worm Caenorhab. elegans Q9XVV3 416 46752 Q406 I T E L L S I Q E E E S V N V
Sea Urchin Strong. purpuratus XP_794533 367 40609 T358 T P F H T L L T D L Y K K N E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 44.5 N.A. 99.7 N.A. 98.9 27.5 N.A. N.A. 97.1 91.1 26.2 N.A. 40.4 42.3 28.8 56.3
Protein Similarity: 100 60.7 N.A. 99.7 N.A. 99.2 46.1 N.A. N.A. 98.1 94.5 45 N.A. 56.6 55.7 43.9 70.9
P-Site Identity: 100 0 N.A. 100 N.A. 100 40 N.A. N.A. 100 93.3 40 N.A. 46.6 6.6 0 40
P-Site Similarity: 100 6.6 N.A. 100 N.A. 100 46.6 N.A. N.A. 100 100 46.6 N.A. 60 26.6 26.6 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 9 9 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 75 0 9 9 0 0 42 % D
% Glu: 0 0 9 17 0 9 9 0 9 9 9 0 0 0 9 % E
% Phe: 0 0 9 0 0 0 0 0 0 0 0 0 9 0 0 % F
% Gly: 9 9 0 0 0 0 0 0 0 0 0 0 0 17 0 % G
% His: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 25 0 75 9 0 9 34 0 9 9 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 9 0 0 0 0 50 9 9 17 % K
% Leu: 0 0 0 9 9 67 50 9 9 9 17 17 0 0 0 % L
% Met: 0 0 0 0 9 0 0 0 0 67 0 9 9 0 0 % M
% Asn: 0 9 0 0 0 0 0 0 0 0 0 0 0 17 9 % N
% Pro: 0 67 0 9 9 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 9 0 0 0 0 9 0 0 % Q
% Arg: 0 0 0 0 50 0 0 25 0 0 0 0 0 9 0 % R
% Ser: 0 0 0 0 0 9 0 50 0 0 0 17 59 42 17 % S
% Thr: 25 17 9 42 25 0 0 9 0 0 0 0 0 0 0 % T
% Val: 42 0 0 9 0 9 0 0 0 0 0 0 9 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 59 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _