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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKAB1 All Species: 26.97
Human Site: S108 Identified Species: 42.38
UniProt: Q9Y478 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.43
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y478 NP_006244.2 270 30382 S108 S K L P L T R S H N N F V A I
Chimpanzee Pan troglodytes XP_513749 272 30341 K107 S T K I P L I K S H N D F V A
Rhesus Macaque Macaca mulatta XP_001093423 272 30312 K107 S T K I P L I K S H N D F V A
Dog Lupus familis XP_543421 270 30281 S108 S K L P L T R S H N N F V A I
Cat Felis silvestris
Mouse Mus musculus Q9R078 270 30290 S108 S K L P L T R S Q N N F V A I
Rat Rattus norvegicus P80386 270 30376 S108 S K L P L T R S Q N N F V A I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514296 285 32181 K120 S A K I P L I K S H N D F V A
Chicken Gallus gallus NP_001035001 273 30440 S111 S K I P L T R S H N N F V A I
Frog Xenopus laevis NP_001085572 266 29829 S104 A K I P L I R S R N N F F A I
Zebra Danio Brachydanio rerio NP_001002632 268 30343 R105 T N K I P L I R S Q N N F V A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610460 341 36399 S185 K P M A M V R S H Q N F V T I
Honey Bee Apis mellifera XP_393160 283 31818 S127 K T L P M V K S H G D F V T I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797535 279 30846 K112 N T K I P M I K S Q G D F T A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SCY5 289 31974 R132 K T R S R L Q R S G K D F T I
Baker's Yeast Sacchar. cerevisiae P34164 415 46386 P194 R K M I G L I P D S D N N G S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 70.5 70.9 98.5 N.A. 96.6 96.3 N.A. 63.8 91.2 80.3 81.1 N.A. 43.9 50.1 N.A. 49.4
Protein Similarity: 100 82.3 82.3 98.8 N.A. 97.7 98.5 N.A. 71.9 94.8 87.7 89.6 N.A. 54.8 66 N.A. 65.2
P-Site Identity: 100 13.3 13.3 100 N.A. 93.3 93.3 N.A. 13.3 93.3 66.6 6.6 N.A. 46.6 46.6 N.A. 0
P-Site Similarity: 100 20 20 100 N.A. 93.3 93.3 N.A. 20 100 80 13.3 N.A. 60 66.6 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 32.8 28.1 N.A.
Protein Similarity: N.A. N.A. N.A. 48.7 39.5 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 0 7 0 0 0 0 0 0 0 0 0 40 34 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 7 0 14 34 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 54 47 0 0 % F
% Gly: 0 0 0 0 7 0 0 0 0 14 7 0 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 34 20 0 0 0 0 0 % H
% Ile: 0 0 14 40 0 7 40 0 0 0 0 0 0 0 60 % I
% Lys: 20 47 34 0 0 0 7 27 0 0 7 0 0 0 0 % K
% Leu: 0 0 34 0 40 40 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 14 0 14 7 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 7 0 0 0 0 0 0 0 40 74 14 7 0 0 % N
% Pro: 0 7 0 47 34 0 0 7 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 7 0 14 20 0 0 0 0 0 % Q
% Arg: 7 0 7 0 7 0 47 14 7 0 0 0 0 0 0 % R
% Ser: 54 0 0 7 0 0 0 54 40 7 0 0 0 0 7 % S
% Thr: 7 34 0 0 0 34 0 0 0 0 0 0 0 27 0 % T
% Val: 0 0 0 0 0 14 0 0 0 0 0 0 47 27 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _