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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WDR45
All Species:
22.73
Human Site:
S275
Identified Species:
41.67
UniProt:
Q9Y484
Number Species:
12
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y484
NP_001025067.1
360
39868
S275
D
T
R
L
N
R
R
S
A
L
A
R
V
G
K
Chimpanzee
Pan troglodytes
XP_001141167
371
41025
S286
D
T
R
L
N
R
R
S
A
L
A
R
V
G
K
Rhesus Macaque
Macaca mulatta
XP_001114123
326
36142
E242
T
V
H
I
F
A
A
E
D
P
K
R
N
K
Q
Dog
Lupus familis
XP_851475
360
39762
S275
D
T
R
L
N
R
R
S
A
L
A
R
V
G
K
Cat
Felis silvestris
Mouse
Mus musculus
Q91VM3
360
39769
S275
D
T
R
L
N
R
R
S
A
L
A
R
V
G
K
Rat
Rattus norvegicus
Q5U2Y0
309
34568
L226
R
L
N
R
R
S
A
L
A
R
V
G
K
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZL16
344
38071
D261
V
H
I
F
A
A
E
D
P
K
R
N
K
Q
S
Frog
Xenopus laevis
Q6DCV0
355
39215
S270
D
T
K
L
N
R
R
S
A
L
A
R
V
G
K
Zebra Danio
Brachydanio rerio
Q7ZUX3
358
39623
S273
D
T
K
L
N
R
R
S
A
L
A
R
V
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396197
345
37993
D262
V
H
I
F
A
L
K
D
T
Q
L
N
R
R
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_790559
342
38268
D259
V
H
I
F
A
L
K
D
S
S
L
N
K
R
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P50079
448
51217
N307
E
T
T
N
T
E
T
N
T
P
D
H
S
R
A
Red Bread Mold
Neurospora crassa
Q96U88
461
50001
A298
N
T
Q
K
N
A
N
A
L
P
G
G
G
P
A
Conservation
Percent
Protein Identity:
100
97
46.1
98
N.A.
97.7
84.1
N.A.
N.A.
46.3
87.5
90
N.A.
N.A.
58.6
N.A.
41.3
Protein Similarity:
100
97
62.2
99.4
N.A.
99.7
85.5
N.A.
N.A.
63
95
96.3
N.A.
N.A.
78
N.A.
54.7
P-Site Identity:
100
100
6.6
100
N.A.
100
6.6
N.A.
N.A.
0
93.3
93.3
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
100
20
100
N.A.
100
6.6
N.A.
N.A.
0
100
100
N.A.
N.A.
6.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.7
25.3
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.6
40.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
24
24
16
8
54
0
47
0
0
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
0
0
0
0
0
0
24
8
0
8
0
0
0
0
% D
% Glu:
8
0
0
0
0
8
8
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
24
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
8
16
8
47
8
% G
% His:
0
24
8
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
24
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
16
8
0
0
16
0
0
8
8
0
24
8
47
% K
% Leu:
0
8
0
47
0
16
0
8
8
47
16
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
8
8
54
0
8
8
0
0
0
24
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
24
0
0
0
8
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
8
0
0
0
8
8
% Q
% Arg:
8
0
31
8
8
47
47
0
0
8
8
54
8
24
0
% R
% Ser:
0
0
0
0
0
8
0
47
8
8
0
0
8
0
24
% S
% Thr:
8
62
8
0
8
0
8
0
16
0
0
0
0
0
0
% T
% Val:
24
8
0
0
0
0
0
0
0
0
8
0
47
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _