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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HYOU1 All Species: 18.79
Human Site: Y531 Identified Species: 31.79
UniProt: Q9Y4L1 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y4L1 NP_001124463.1 999 111335 Y531 V G D S F K K Y P D Y E S K G
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001096142 916 102146 Y448 V G D S F K K Y P D Y E S K G
Dog Lupus familis XP_536547 1100 121754 Y531 V G E S F K K Y P D Y E S K G
Cat Felis silvestris
Mouse Mus musculus Q9JKR6 999 111163 Y531 V G E S F K K Y P D Y E S K G
Rat Rattus norvegicus Q63617 999 111271 Y531 V G E S F K K Y P D Y E S K G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZLK7 1002 112301 H523 V G E S F K K H S D Y E S K G
Frog Xenopus laevis Q566I3 646 72655 L249 D S G T Q P Q L Q I R G V G F
Zebra Danio Brachydanio rerio Q7ZUW2 980 110301 H521 V G S S F K K H S D A E S K G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8INI8 641 70177 K244 T H L A E E F K R K Y K K D L
Honey Bee Apis mellifera XP_624153 932 105575 K516 E A L D K H L K D G A E S K G
Nematode Worm Caenorhab. elegans P09446 640 69704 C243 N R M V N H F C A E F K R K H
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002322555 881 98313 M472 M R K L P S K M F R S I I H T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_567510 867 96706 S466 P R M K K L P S K M F R S F V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa O74225 707 78655 P310 E F E A M V E P L L A K V H V
Conservation
Percent
Protein Identity: 100 N.A. 89 83.3 N.A. 92 91.6 N.A. N.A. 69.1 49.3 65.3 N.A. 24.5 42.4 24.6 N.A.
Protein Similarity: 100 N.A. 90 86 N.A. 95.5 94.7 N.A. N.A. 80.7 56.4 77.4 N.A. 38.7 60 39.5 N.A.
P-Site Identity: 100 N.A. 100 93.3 N.A. 93.3 93.3 N.A. N.A. 80 0 73.3 N.A. 6.6 26.6 6.6 N.A.
P-Site Similarity: 100 N.A. 100 100 N.A. 100 100 N.A. N.A. 93.3 13.3 80 N.A. 26.6 26.6 26.6 N.A.
Percent
Protein Identity: 29.7 N.A. N.A. 30.7 N.A. 26.5
Protein Similarity: 50.7 N.A. N.A. 49 N.A. 43.1
P-Site Identity: 6.6 N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 13.3 N.A. N.A. 13.3 N.A. 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 15 0 0 0 0 8 0 22 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 8 0 15 8 0 0 0 0 8 50 0 0 0 8 0 % D
% Glu: 15 0 36 0 8 8 8 0 0 8 0 58 0 0 0 % E
% Phe: 0 8 0 0 50 0 15 0 8 0 15 0 0 8 8 % F
% Gly: 0 50 8 0 0 0 0 0 0 8 0 8 0 8 58 % G
% His: 0 8 0 0 0 15 0 15 0 0 0 0 0 15 8 % H
% Ile: 0 0 0 0 0 0 0 0 0 8 0 8 8 0 0 % I
% Lys: 0 0 8 8 15 50 58 15 8 8 0 22 8 65 0 % K
% Leu: 0 0 15 8 0 8 8 8 8 8 0 0 0 0 8 % L
% Met: 8 0 15 0 8 0 0 8 0 8 0 0 0 0 0 % M
% Asn: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 8 0 0 0 8 8 8 8 36 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 8 0 8 0 8 0 0 0 0 0 0 % Q
% Arg: 0 22 0 0 0 0 0 0 8 8 8 8 8 0 0 % R
% Ser: 0 8 8 50 0 8 0 8 15 0 8 0 65 0 0 % S
% Thr: 8 0 0 8 0 0 0 0 0 0 0 0 0 0 8 % T
% Val: 50 0 0 8 0 8 0 0 0 0 0 0 15 0 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 36 0 0 50 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _