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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AFG3L2 All Species: 45.45
Human Site: S754 Identified Species: 76.92
UniProt: Q9Y4W6 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y4W6 NP_006787.1 797 88584 S754 P R P F A E K S T Y E E F V E
Chimpanzee Pan troglodytes XP_512199 797 88551 S754 P R P F A E K S T Y E E F V E
Rhesus Macaque Macaca mulatta XP_001094146 798 88780 S755 P R P F A E K S T Y E E F V E
Dog Lupus familis XP_547682 806 89781 S755 P R P F V E K S T Y E E F V E
Cat Felis silvestris
Mouse Mus musculus Q8JZQ2 802 89500 S753 P R P F T E K S T Y E E F V E
Rat Rattus norvegicus Q7TT47 744 82104 H715 A L I G P P P H G P K K M I A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510851 790 87620 S739 P R P F A E K S T Y E E F V E
Chicken Gallus gallus XP_419121 806 89372 S755 P R P F A E K S T Y E E F V E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001104667 800 88678 S749 K R P F A E K S T Y E E F V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_730248 826 89682 S772 P R P F K E K S T Y E E F V E
Honey Bee Apis mellifera XP_624548 803 91087 S745 P R P F P E K S T Y E Q F V E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783782 792 87074 T747 K R P F A E R T T Y E D F V E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8VZI8 813 89536 T772 P F K S G E T T N Y D R F K S
Baker's Yeast Sacchar. cerevisiae P40341 825 93258 N792 K R P F P E R N D A F D K Y L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 98.6 94.2 N.A. 92.6 36.1 N.A. 72.7 80.8 N.A. 81 N.A. 60.6 61.3 N.A. 63.3
Protein Similarity: 100 100 99.1 95.9 N.A. 95.2 52.7 N.A. 82.4 87.7 N.A. 88.1 N.A. 73 75.2 N.A. 76.7
P-Site Identity: 100 100 100 93.3 N.A. 93.3 0 N.A. 100 100 N.A. 93.3 N.A. 93.3 86.6 N.A. 73.3
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 20 N.A. 100 100 N.A. 93.3 N.A. 93.3 93.3 N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. 45.5 47 N.A.
Protein Similarity: N.A. N.A. N.A. 61 62.3 N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 50 0 0 0 0 8 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 8 0 8 15 0 0 0 % D
% Glu: 0 0 0 0 0 93 0 0 0 0 79 65 0 0 79 % E
% Phe: 0 8 0 86 0 0 0 0 0 0 8 0 86 0 0 % F
% Gly: 0 0 0 8 8 0 0 0 8 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 22 0 8 0 8 0 72 0 0 0 8 8 8 8 0 % K
% Leu: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % N
% Pro: 72 0 86 0 22 8 8 0 0 8 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Q
% Arg: 0 86 0 0 0 0 15 0 0 0 0 8 0 0 0 % R
% Ser: 0 0 0 8 0 0 0 72 0 0 0 0 0 0 8 % S
% Thr: 0 0 0 0 8 0 8 15 79 0 0 0 0 0 0 % T
% Val: 0 0 0 0 8 0 0 0 0 0 0 0 0 79 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 86 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _