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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HES2 All Species: 12.42
Human Site: S136 Identified Species: 27.33
UniProt: Q9Y543 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y543 NP_061962.2 173 18470 S136 D G G R A G D S S G P S A P A
Chimpanzee Pan troglodytes XP_514337 173 18438 S136 D G G R A G D S S G P S A P A
Rhesus Macaque Macaca mulatta XP_001092640 173 18491 S136 D G G R A G D S G G P S A P A
Dog Lupus familis XP_849965 165 17986 A130 A S G P A P D A G R A G D P C
Cat Felis silvestris
Mouse Mus musculus O54792 157 17213 T123 L E H L R Q R T V S D D S P S
Rat Rattus norvegicus P35429 157 17009 T123 L E H L R Q R T V S G G P P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521383 168 18161 R135 S P R G S K A R G P D P R A A
Chicken Gallus gallus O57337 290 31053 L157 Q I V A M N Y L P P P P A G Q
Frog Xenopus laevis Q00P32 191 21805 P147 D C N H P P K P Q R P R I V L
Zebra Danio Brachydanio rerio Q8AXV5 310 33373 T259 Q H S P E G R T V P S S S S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26263 435 46532 N230 E F A L I M P N T G S A A P P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 96.5 71 N.A. 67.6 70.5 N.A. 62.4 32.4 45.5 22.8 N.A. 21.1 N.A. N.A. N.A.
Protein Similarity: 100 99.4 97.6 76.8 N.A. 75.7 74.5 N.A. 74.5 40.6 57 31.2 N.A. 28 N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 26.6 N.A. 6.6 6.6 N.A. 6.6 13.3 13.3 13.3 N.A. 20 N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 33.3 N.A. 26.6 20 N.A. 13.3 13.3 13.3 33.3 N.A. 46.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 10 37 0 10 10 0 0 10 10 46 10 37 % A
% Cys: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 37 0 0 0 0 0 37 0 0 0 19 10 10 0 0 % D
% Glu: 10 19 0 0 10 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 28 37 10 0 37 0 0 28 37 10 19 0 10 0 % G
% His: 0 10 19 10 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 10 0 0 10 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 0 0 0 0 0 10 10 0 0 0 0 0 0 0 0 % K
% Leu: 19 0 0 28 0 0 0 10 0 0 0 0 0 0 10 % L
% Met: 0 0 0 0 10 10 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 10 0 10 0 0 0 0 0 0 0 % N
% Pro: 0 10 0 19 10 19 10 10 10 28 46 19 10 64 10 % P
% Gln: 19 0 0 0 0 19 0 0 10 0 0 0 0 0 10 % Q
% Arg: 0 0 10 28 19 0 28 10 0 19 0 10 10 0 0 % R
% Ser: 10 10 10 0 10 0 0 28 19 19 19 37 19 10 28 % S
% Thr: 0 0 0 0 0 0 0 28 10 0 0 0 0 0 0 % T
% Val: 0 0 10 0 0 0 0 0 28 0 0 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _