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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HES2
All Species:
23.94
Human Site:
S49
Identified Species:
52.67
UniProt:
Q9Y543
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y543
NP_061962.2
173
18470
S49
P
L
L
G
R
E
N
S
N
C
S
K
L
E
K
Chimpanzee
Pan troglodytes
XP_514337
173
18438
S49
P
L
L
G
R
E
V
S
D
C
S
K
L
E
K
Rhesus Macaque
Macaca mulatta
XP_001092640
173
18491
S49
P
L
L
G
R
E
N
S
N
C
S
K
L
E
K
Dog
Lupus familis
XP_849965
165
17986
S49
P
L
L
G
R
E
S
S
H
Y
S
K
L
E
K
Cat
Felis silvestris
Mouse
Mus musculus
O54792
157
17213
P42
Q
L
K
G
L
V
L
P
L
L
G
A
E
T
S
Rat
Rattus norvegicus
P35429
157
17009
L41
S
Q
L
K
G
L
V
L
P
L
L
G
A
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521383
168
18161
S49
P
L
I
G
K
D
S
S
R
Y
S
K
L
E
K
Chicken
Gallus gallus
O57337
290
31053
S71
D
A
L
K
K
D
S
S
R
H
S
K
L
E
K
Frog
Xenopus laevis
Q00P32
191
21805
S64
P
L
I
G
K
D
N
S
R
Y
S
K
L
E
K
Zebra Danio
Brachydanio rerio
Q8AXV5
310
33373
Q77
V
P
S
A
F
E
K
Q
G
S
S
K
L
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26263
435
46532
A76
E
A
M
K
K
D
P
A
R
H
T
K
L
E
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
96.5
71
N.A.
67.6
70.5
N.A.
62.4
32.4
45.5
22.8
N.A.
21.1
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
97.6
76.8
N.A.
75.7
74.5
N.A.
74.5
40.6
57
31.2
N.A.
28
N.A.
N.A.
N.A.
P-Site Identity:
100
86.6
100
80
N.A.
13.3
13.3
N.A.
60
46.6
66.6
40
N.A.
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
100
93.3
N.A.
13.3
13.3
N.A.
86.6
66.6
86.6
40
N.A.
60
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
0
10
0
0
0
10
0
0
0
10
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
28
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
37
0
0
10
0
0
0
0
0
0
% D
% Glu:
10
0
0
0
0
46
0
0
0
0
0
0
10
91
0
% E
% Phe:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
64
10
0
0
0
10
0
10
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
10
19
0
0
0
0
0
% H
% Ile:
0
0
19
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
10
28
37
0
10
0
0
0
0
82
0
0
82
% K
% Leu:
0
64
55
0
10
10
10
10
10
19
10
0
82
0
0
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
28
0
19
0
0
0
0
0
0
% N
% Pro:
55
10
0
0
0
0
10
10
10
0
0
0
0
0
0
% P
% Gln:
10
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
37
0
0
0
37
0
0
0
0
0
0
% R
% Ser:
10
0
10
0
0
0
28
64
0
10
73
0
0
0
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
10
% T
% Val:
10
0
0
0
0
10
19
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
28
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _