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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPME1 All Species: 25.15
Human Site: S249 Identified Species: 36.89
UniProt: Q9Y570 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y570 NP_057231.1 386 42315 S249 T S P E G S K S I V E G I I E
Chimpanzee Pan troglodytes XP_508638 381 41876 S249 T S P E G S K S I V E G I I E
Rhesus Macaque Macaca mulatta XP_001115651 405 44400 S249 T S P E G S K S I V E G I I E
Dog Lupus familis XP_850122 386 42276 S249 T S P E G S K S I V E G I I E
Cat Felis silvestris
Mouse Mus musculus Q8BVQ5 386 42238 S249 T S P E G S K S I V E G I I E
Rat Rattus norvegicus XP_341892 386 42298 S249 T S P E S S K S I V E G I I E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517056 352 38800 H249 D T E T K K D H P Y T W R I E
Chicken Gallus gallus NP_001026005 359 39669 Y258 E T K K E H L Y T W R I E L T
Frog Xenopus laevis NP_001086882 386 42454 V249 P E G P K A I V E G I I E E E
Zebra Danio Brachydanio rerio Q6DRD9 317 34905 F219 K E R S V R Q F L L T N L E E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648277 409 45331 V249 D L P L P D D V L E E A H H N
Honey Bee Apis mellifera XP_623299 384 41915 T252 T C Q C I S E T T I P R E D I
Nematode Worm Caenorhab. elegans Q9BIB3 364 40203 D257 H E Y T W R I D L T T T E Q Y
Sea Urchin Strong. purpuratus XP_001202410 365 39617 T255 P Q S S T Q A T A S A S S S S
Poplar Tree Populus trichocarpa XP_002325511 354 39103 R254 K C Y V Y R T R L E E T E Q Y
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SGG8 454 48937 L334 Q R P E L Q Q L P R G V A G T
Conservation
Percent
Protein Identity: 100 98.4 90.3 98.4 N.A. 97.9 97.9 N.A. 86.2 84.7 85.2 20.4 N.A. 47.4 52 42.4 59.5
Protein Similarity: 100 98.6 91.3 98.9 N.A. 99.4 99.4 N.A. 88.5 87.8 93 40.4 N.A. 67.2 70.9 58.8 72.8
P-Site Identity: 100 100 100 100 N.A. 100 93.3 N.A. 13.3 0 6.6 6.6 N.A. 13.3 13.3 0 0
P-Site Similarity: 100 100 100 100 N.A. 100 93.3 N.A. 20 20 13.3 33.3 N.A. 20 33.3 6.6 6.6
Percent
Protein Identity: 43.5 N.A. N.A. N.A. N.A. 36.1
Protein Similarity: 60.3 N.A. N.A. N.A. N.A. 51.3
P-Site Identity: 6.6 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 13.3 N.A. N.A. N.A. N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 7 0 7 0 7 7 7 0 0 % A
% Cys: 0 13 0 7 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 13 0 0 0 0 7 13 7 0 0 0 0 0 7 0 % D
% Glu: 7 19 7 44 7 0 7 0 7 13 50 0 32 13 57 % E
% Phe: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % F
% Gly: 0 0 7 0 32 0 0 0 0 7 7 38 0 7 0 % G
% His: 7 0 0 0 0 7 0 7 0 0 0 0 7 7 0 % H
% Ile: 0 0 0 0 7 0 13 0 38 7 7 13 38 44 7 % I
% Lys: 13 0 7 7 13 7 38 0 0 0 0 0 0 0 0 % K
% Leu: 0 7 0 7 7 0 7 7 25 7 0 0 7 7 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 7 % N
% Pro: 13 0 50 7 7 0 0 0 13 0 7 0 0 0 0 % P
% Gln: 7 7 7 0 0 13 13 0 0 0 0 0 0 13 0 % Q
% Arg: 0 7 7 0 0 19 0 7 0 7 7 7 7 0 0 % R
% Ser: 0 38 7 13 7 44 0 38 0 7 0 7 7 7 7 % S
% Thr: 44 13 0 13 7 0 7 13 13 7 19 13 0 0 13 % T
% Val: 0 0 0 7 7 0 0 13 0 38 0 7 0 0 0 % V
% Trp: 0 0 0 0 7 0 0 0 0 7 0 7 0 0 0 % W
% Tyr: 0 0 13 0 7 0 0 7 0 7 0 0 0 0 13 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _