Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GMPPB All Species: 58.48
Human Site: S78 Identified Species: 80.42
UniProt: Q9Y5P6 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y5P6 NP_037466.2 360 39834 S78 L G I R I S M S H E E E P L G
Chimpanzee Pan troglodytes XP_001165804 387 42605 S78 L G I R I S M S H E E E P L G
Rhesus Macaque Macaca mulatta XP_001106890 360 39913 S78 L G I R I S M S H E E E P L G
Dog Lupus familis XP_850642 876 95988 S78 L G I R I S M S H E E E P L G
Cat Felis silvestris
Mouse Mus musculus Q8BTZ7 360 39898 S78 L G I R I S M S H E E E P L G
Rat Rattus norvegicus Q5XIC1 420 46173 L83 F N L P V R Y L Q E F T P L G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_414268 439 48772 S157 L G I R I S L S H E K E P L G
Frog Xenopus laevis Q68EY9 360 40133 S78 L G I R I S M S H E K E P L G
Zebra Danio Brachydanio rerio Q6DBU5 360 40125 S78 L G I K I S L S H E K E P L G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7JZB4 369 40430 S88 L G V E L I F S H E T E P L G
Honey Bee Apis mellifera XP_392845 359 39840 S78 L G V H L I F S H E P E P L G
Nematode Worm Caenorhab. elegans A3QMC8 365 40081 S78 L G V K L I F S L E E E P L G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002316262 361 39591 S78 L E I K I T C S Q E T E P L G
Maize Zea mays NP_001142302 361 39566 S78 L G I T I T C S Q E T E P L G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_181507 361 39559 S78 L E I K I T C S Q E T E P L G
Baker's Yeast Sacchar. cerevisiae P41940 361 39547 S78 Y G V N I T F S V E T E P L G
Red Bread Mold Neurospora crassa Q7RVR8 364 40035 S78 F G I N I T I S I E S E P L G
Conservation
Percent
Protein Identity: 100 92.7 99.1 39.8 N.A. 98 33.8 N.A. N.A. 61.5 82.2 81.1 N.A. 68.5 66.3 63 N.A.
Protein Similarity: 100 93 99.4 40.7 N.A. 99.1 48.5 N.A. N.A. 71.5 92.2 93.3 N.A. 84.2 83.6 76.7 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 26.6 N.A. N.A. 86.6 93.3 80 N.A. 60 60 60 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 40 N.A. N.A. 100 100 100 N.A. 73.3 73.3 80 N.A.
Percent
Protein Identity: 61.2 61.7 N.A. 61.7 57.8 59.6
Protein Similarity: 79.5 79.5 N.A. 79.5 77 79.1
P-Site Identity: 60 66.6 N.A. 60 53.3 60
P-Site Similarity: 73.3 73.3 N.A. 73.3 66.6 73.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 18 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 12 0 6 0 0 0 0 0 100 36 95 0 0 0 % E
% Phe: 12 0 0 0 0 0 24 0 0 0 6 0 0 0 0 % F
% Gly: 0 83 0 0 0 0 0 0 0 0 0 0 0 0 100 % G
% His: 0 0 0 6 0 0 0 0 59 0 0 0 0 0 0 % H
% Ile: 0 0 71 0 77 18 6 0 6 0 0 0 0 0 0 % I
% Lys: 0 0 0 24 0 0 0 0 0 0 18 0 0 0 0 % K
% Leu: 83 0 6 0 18 0 12 6 6 0 0 0 0 100 0 % L
% Met: 0 0 0 0 0 0 36 0 0 0 0 0 0 0 0 % M
% Asn: 0 6 0 12 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 6 0 0 0 0 0 0 6 0 100 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 24 0 0 0 0 0 0 % Q
% Arg: 0 0 0 42 0 6 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 48 0 95 0 0 6 0 0 0 0 % S
% Thr: 0 0 0 6 0 30 0 0 0 0 30 6 0 0 0 % T
% Val: 0 0 24 0 6 0 0 0 6 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 6 0 0 0 0 0 6 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _