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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEMK1
All Species:
20.61
Human Site:
S290
Identified Species:
50.37
UniProt:
Q9Y5R4
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y5R4
NP_057257.1
338
38231
S290
R
L
L
K
D
S
G
S
I
F
L
E
V
D
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001097923
338
38085
S290
R
L
L
K
D
S
G
S
I
F
L
E
V
D
P
Dog
Lupus familis
XP_533816
358
39937
S291
W
L
L
K
D
S
G
S
I
F
L
E
V
D
P
Cat
Felis silvestris
Mouse
Mus musculus
Q921L7
340
38190
S292
Q
L
L
N
A
S
G
S
I
F
L
E
V
D
P
Rat
Rattus norvegicus
NP_001100323
340
38149
S292
W
L
L
N
A
S
G
S
I
F
L
E
V
D
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516646
137
15225
Q97
A
I
Q
L
T
R
I
Q
E
L
S
S
L
R
L
Chicken
Gallus gallus
XP_414261
352
39553
S304
T
L
L
K
D
S
G
S
V
F
L
E
V
D
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001107891
342
38728
R293
K
L
L
T
K
Q
G
R
V
Y
L
E
V
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393324
349
39667
R303
I
A
L
K
P
G
G
R
L
F
L
E
V
D
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001201549
390
44295
F330
F
L
L
K
P
R
G
F
I
W
L
E
T
D
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
95.2
80.4
N.A.
77.3
78.5
N.A.
23.3
55.9
N.A.
42.6
N.A.
N.A.
36.9
N.A.
33.8
Protein Similarity:
100
N.A.
97.9
84.6
N.A.
87.3
88.5
N.A.
29.2
70.4
N.A.
57.3
N.A.
N.A.
54.7
N.A.
47.9
P-Site Identity:
100
N.A.
100
93.3
N.A.
80
80
N.A.
0
86.6
N.A.
40
N.A.
N.A.
53.3
N.A.
53.3
P-Site Similarity:
100
N.A.
100
93.3
N.A.
86.6
80
N.A.
13.3
93.3
N.A.
60
N.A.
N.A.
60
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
0
20
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
40
0
0
0
0
0
0
0
0
80
0
% D
% Glu:
0
0
0
0
0
0
0
0
10
0
0
90
0
0
0
% E
% Phe:
10
0
0
0
0
0
0
10
0
70
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
90
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
10
0
0
0
0
10
0
60
0
0
0
0
0
0
% I
% Lys:
10
0
0
60
10
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
80
90
10
0
0
0
0
10
10
90
0
10
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
20
0
0
0
0
0
0
0
0
0
60
% P
% Gln:
10
0
10
0
0
10
0
10
0
0
0
0
0
0
0
% Q
% Arg:
20
0
0
0
0
20
0
20
0
0
0
0
0
10
0
% R
% Ser:
0
0
0
0
0
60
0
60
0
0
10
10
0
10
10
% S
% Thr:
10
0
0
10
10
0
0
0
0
0
0
0
10
0
20
% T
% Val:
0
0
0
0
0
0
0
0
20
0
0
0
80
0
0
% V
% Trp:
20
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _