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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BACE2
All Species:
22.73
Human Site:
S510
Identified Species:
45.45
UniProt:
Q9Y5Z0
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y5Z0
NP_036237.2
518
56180
S510
P
E
V
V
N
D
E
S
S
L
V
R
H
R
W
Chimpanzee
Pan troglodytes
XP_001171642
518
56196
S510
P
E
V
V
N
D
E
S
S
L
V
R
H
R
W
Rhesus Macaque
Macaca mulatta
XP_001108061
438
47471
S431
K
R
V
G
F
A
A
S
P
C
A
G
E
R
F
Dog
Lupus familis
XP_535595
422
46339
S415
E
V
V
N
D
E
S
S
L
V
R
H
R
W
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9JL18
514
55782
S506
P
E
V
V
N
D
E
S
S
L
V
R
H
R
W
Rat
Rattus norvegicus
Q6IE75
514
55840
S506
P
E
V
V
N
D
E
S
S
L
V
R
H
R
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511090
553
60415
S545
P
D
T
V
N
D
E
S
S
L
V
R
H
R
W
Chicken
Gallus gallus
Q05744
398
43280
S391
V
F
D
R
D
N
D
S
V
G
F
A
K
C
V
Frog
Xenopus laevis
Q805F3
397
42889
Y390
G
L
A
P
V
V
P
Y
P
P
L
K
N
G
V
Zebra Danio
Brachydanio rerio
NP_991267
505
55643
G497
C
C
L
Q
P
A
D
G
S
D
D
I
S
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P55956
398
43395
F391
H
G
N
K
R
V
G
F
A
T
S
R
T
G
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07267
405
44480
A398
I
Y
D
L
G
N
N
A
V
G
L
A
K
A
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
83.1
75.8
N.A.
88.6
89
N.A.
67.2
26.6
22.9
45.1
N.A.
N.A.
N.A.
20
N.A.
Protein Similarity:
100
99.8
83.5
78.5
N.A.
92.4
92.6
N.A.
76.4
41.1
40.1
61.9
N.A.
N.A.
N.A.
33.7
N.A.
P-Site Identity:
100
100
20
13.3
N.A.
100
100
N.A.
86.6
6.6
0
6.6
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
26.6
33.3
N.A.
100
100
N.A.
93.3
26.6
20
20
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
17
9
9
9
0
9
17
0
9
0
% A
% Cys:
9
9
0
0
0
0
0
0
0
9
0
0
0
9
0
% C
% Asp:
0
9
17
0
17
42
17
0
0
9
9
0
0
0
0
% D
% Glu:
9
34
0
0
0
9
42
0
0
0
0
0
9
0
0
% E
% Phe:
0
9
0
0
9
0
0
9
0
0
9
0
0
0
9
% F
% Gly:
9
9
0
9
9
0
9
9
0
17
0
9
0
17
0
% G
% His:
9
0
0
0
0
0
0
0
0
0
0
9
42
0
0
% H
% Ile:
9
0
0
0
0
0
0
0
0
0
0
9
0
0
9
% I
% Lys:
9
0
0
9
0
0
0
0
0
0
0
9
17
0
17
% K
% Leu:
0
9
9
9
0
0
0
0
9
42
17
0
0
9
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
9
42
17
9
0
0
0
0
0
9
0
0
% N
% Pro:
42
0
0
9
9
0
9
0
17
9
0
0
0
0
0
% P
% Gln:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
0
9
9
0
0
0
0
0
9
50
9
50
0
% R
% Ser:
0
0
0
0
0
0
9
67
50
0
9
0
9
0
0
% S
% Thr:
0
0
9
0
0
0
0
0
0
9
0
0
9
0
0
% T
% Val:
9
9
50
42
9
17
0
0
17
9
42
0
0
0
17
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
42
% W
% Tyr:
0
9
0
0
0
0
0
9
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _