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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BACE2
All Species:
22.42
Human Site:
Y295
Identified Species:
44.85
UniProt:
Q9Y5Z0
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y5Z0
NP_036237.2
518
56180
Y295
L
N
L
D
C
R
E
Y
N
A
D
K
A
I
V
Chimpanzee
Pan troglodytes
XP_001171642
518
56196
Y295
L
N
L
D
C
R
E
Y
N
A
D
K
A
I
V
Rhesus Macaque
Macaca mulatta
XP_001108061
438
47471
V239
M
C
G
A
G
L
P
V
A
G
S
G
T
N
G
Dog
Lupus familis
XP_535595
422
46339
V223
P
Q
K
V
F
N
A
V
V
E
A
V
A
R
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9JL18
514
55782
Y291
L
N
L
D
C
R
E
Y
N
A
D
K
A
I
V
Rat
Rattus norvegicus
Q6IE75
514
55840
Y291
L
N
L
D
C
R
E
Y
N
A
D
K
A
I
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511090
553
60415
Y330
L
N
L
D
C
R
E
Y
N
A
N
K
A
I
V
Chicken
Gallus gallus
Q05744
398
43280
V199
P
R
I
S
V
D
K
V
T
P
F
F
D
N
V
Frog
Xenopus laevis
Q805F3
397
42889
D198
G
D
C
T
P
V
F
D
N
M
I
A
Q
N
L
Zebra Danio
Brachydanio rerio
NP_991267
505
55643
Y287
L
N
M
D
C
K
E
Y
N
Y
D
K
S
I
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P55956
398
43395
D199
N
K
I
S
Q
P
M
D
Q
I
F
A
N
S
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07267
405
44480
S206
G
L
G
Y
D
T
I
S
V
D
K
V
V
P
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
83.1
75.8
N.A.
88.6
89
N.A.
67.2
26.6
22.9
45.1
N.A.
N.A.
N.A.
20
N.A.
Protein Similarity:
100
99.8
83.5
78.5
N.A.
92.4
92.6
N.A.
76.4
41.1
40.1
61.9
N.A.
N.A.
N.A.
33.7
N.A.
P-Site Identity:
100
100
0
6.6
N.A.
100
100
N.A.
93.3
6.6
6.6
73.3
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
100
6.6
6.6
N.A.
100
100
N.A.
100
20
20
93.3
N.A.
N.A.
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
9
0
9
42
9
17
50
0
9
% A
% Cys:
0
9
9
0
50
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
50
9
9
0
17
0
9
42
0
9
0
0
% D
% Glu:
0
0
0
0
0
0
50
0
0
9
0
0
0
0
0
% E
% Phe:
0
0
0
0
9
0
9
0
0
0
17
9
0
0
0
% F
% Gly:
17
0
17
0
9
0
0
0
0
9
0
9
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
17
0
0
0
9
0
0
9
9
0
0
50
0
% I
% Lys:
0
9
9
0
0
9
9
0
0
0
9
50
0
0
0
% K
% Leu:
50
9
42
0
0
9
0
0
0
0
0
0
0
0
9
% L
% Met:
9
0
9
0
0
0
9
0
0
9
0
0
0
0
0
% M
% Asn:
9
50
0
0
0
9
0
0
59
0
9
0
9
25
0
% N
% Pro:
17
0
0
0
9
9
9
0
0
9
0
0
0
9
9
% P
% Gln:
0
9
0
0
9
0
0
0
9
0
0
0
9
0
0
% Q
% Arg:
0
9
0
0
0
42
0
0
0
0
0
0
0
9
0
% R
% Ser:
0
0
0
17
0
0
0
9
0
0
9
0
9
9
0
% S
% Thr:
0
0
0
9
0
9
0
0
9
0
0
0
9
0
9
% T
% Val:
0
0
0
9
9
9
0
25
17
0
0
17
9
0
59
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
0
0
50
0
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _