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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BACE2
All Species:
17.58
Human Site:
Y93
Identified Species:
35.15
UniProt:
Q9Y5Z0
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y5Z0
NP_036237.2
518
56180
Y93
G
D
S
G
R
G
Y
Y
L
E
M
L
I
G
T
Chimpanzee
Pan troglodytes
XP_001171642
518
56196
Y93
G
D
S
G
R
G
Y
Y
L
E
M
L
I
G
T
Rhesus Macaque
Macaca mulatta
XP_001108061
438
47471
N40
L
R
V
A
A
A
T
N
R
V
V
A
P
T
P
Dog
Lupus familis
XP_535595
422
46339
G24
S
S
N
F
A
V
A
G
A
P
H
S
Y
T
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9JL18
514
55782
Y89
G
D
S
G
R
G
Y
Y
L
E
M
L
I
G
T
Rat
Rattus norvegicus
Q6IE75
514
55840
Y89
G
D
S
G
R
G
Y
Y
L
E
M
L
I
G
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511090
553
60415
G128
V
A
R
R
A
G
P
G
P
K
L
F
P
S
A
Chicken
Gallus gallus
Q05744
398
43280
Frog
Xenopus laevis
Q805F3
397
42889
Zebra Danio
Brachydanio rerio
NP_991267
505
55643
Y81
G
K
S
G
Q
G
Y
Y
I
E
M
A
V
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P55956
398
43395
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07267
405
44480
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
83.1
75.8
N.A.
88.6
89
N.A.
67.2
26.6
22.9
45.1
N.A.
N.A.
N.A.
20
N.A.
Protein Similarity:
100
99.8
83.5
78.5
N.A.
92.4
92.6
N.A.
76.4
41.1
40.1
61.9
N.A.
N.A.
N.A.
33.7
N.A.
P-Site Identity:
100
100
0
0
N.A.
100
100
N.A.
6.6
0
0
60
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
100
6.6
6.6
N.A.
100
100
N.A.
20
0
0
86.6
N.A.
N.A.
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
9
25
9
9
0
9
0
0
17
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
34
0
0
0
0
0
0
0
0
0
0
0
0
9
% D
% Glu:
0
0
0
0
0
0
0
0
0
42
0
0
0
0
0
% E
% Phe:
0
0
0
9
0
0
0
0
0
0
0
9
0
0
0
% F
% Gly:
42
0
0
42
0
50
0
17
0
0
0
0
0
42
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
9
0
0
0
34
0
0
% I
% Lys:
0
9
0
0
0
0
0
0
0
9
0
0
0
0
0
% K
% Leu:
9
0
0
0
0
0
0
0
34
0
9
34
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
42
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
9
0
9
9
0
0
17
0
9
% P
% Gln:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
9
9
34
0
0
0
9
0
0
0
0
0
0
% R
% Ser:
9
9
42
0
0
0
0
0
0
0
0
9
0
9
9
% S
% Thr:
0
0
0
0
0
0
9
0
0
0
0
0
0
17
34
% T
% Val:
9
0
9
0
0
9
0
0
0
9
9
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
42
42
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _