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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HCFC2
All Species:
20.3
Human Site:
T249
Identified Species:
34.36
UniProt:
Q9Y5Z7
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y5Z7
NP_037452.1
792
86779
T249
P
L
P
R
S
L
H
T
A
S
V
I
G
N
K
Chimpanzee
Pan troglodytes
XP_509326
792
86791
T249
P
L
P
R
S
L
H
T
A
S
V
I
G
N
K
Rhesus Macaque
Macaca mulatta
XP_001097074
792
86781
T249
P
L
P
R
S
L
H
T
A
S
V
I
G
N
K
Dog
Lupus familis
XP_532674
790
86251
T249
P
L
P
R
S
L
H
T
A
S
V
I
G
N
K
Cat
Felis silvestris
Mouse
Mus musculus
Q61191
2045
210519
S256
G
V
A
P
L
P
R
S
L
H
S
A
T
T
I
Rat
Rattus norvegicus
Q5RKG2
723
79130
T194
P
S
P
R
E
S
H
T
A
V
I
Y
C
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507728
758
83389
E223
P
Q
A
V
D
N
V
E
C
S
A
H
D
C
E
Chicken
Gallus gallus
XP_001234928
787
86020
H249
V
P
L
P
R
S
L
H
T
A
N
V
I
G
N
Frog
Xenopus laevis
NP_001087989
2101
219049
S254
G
V
A
P
L
P
R
S
L
H
S
A
T
T
I
Zebra Danio
Brachydanio rerio
NP_001038529
1778
182507
S255
G
A
A
P
L
P
R
S
L
H
S
A
T
T
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V4C8
1500
160166
R297
S
G
E
A
P
L
P
R
S
L
H
S
S
T
M
Honey Bee
Apis mellifera
XP_624189
1550
166762
S244
G
P
I
P
L
P
R
S
L
H
T
A
T
L
I
Nematode Worm
Caenorhab. elegans
NP_501279
782
87341
S214
P
G
P
I
S
R
E
S
H
T
A
V
I
Y
E
Sea Urchin
Strong. purpuratus
XP_791039
1216
126587
S245
G
P
N
P
L
P
R
S
L
H
S
A
T
V
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
99.4
94.8
N.A.
25.9
82
N.A.
72.5
73.7
25.3
28.7
N.A.
29.5
29.2
39.6
32
Protein Similarity:
100
99.8
99.6
97
N.A.
32
86.2
N.A.
80.8
83.9
31.5
36.3
N.A.
40.2
39.6
56
44.3
P-Site Identity:
100
100
100
100
N.A.
0
40
N.A.
13.3
0
0
0
N.A.
6.6
0
20
0
P-Site Similarity:
100
100
100
100
N.A.
13.3
53.3
N.A.
20
13.3
13.3
6.6
N.A.
13.3
6.6
46.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
29
8
0
0
0
0
36
8
15
36
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
8
8
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
0
0
8
0
8
0
8
8
0
0
0
0
0
0
15
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
36
15
0
0
0
0
0
0
0
0
0
0
29
8
0
% G
% His:
0
0
0
0
0
0
36
8
8
36
8
8
0
0
0
% H
% Ile:
0
0
8
8
0
0
0
0
0
0
8
29
15
0
36
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
29
% K
% Leu:
0
29
8
0
36
36
8
0
36
8
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
8
0
0
8
0
0
0
0
8
0
0
29
8
% N
% Pro:
50
22
43
43
8
36
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
36
8
8
36
8
0
0
0
0
0
0
8
% R
% Ser:
8
8
0
0
36
15
0
43
8
36
29
8
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
36
8
8
8
0
36
29
0
% T
% Val:
8
15
0
8
0
0
8
0
0
8
29
15
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _