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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COPG All Species: 48.48
Human Site: S508 Identified Species: 71.11
UniProt: Q9Y678 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y678 NP_057212.1 874 97718 S508 Q N E E M L P S I L V L L K R
Chimpanzee Pan troglodytes XP_001141317 874 97700 S508 Q N E E M L P S I L V L L K R
Rhesus Macaque Macaca mulatta XP_001095932 720 80896 P391 S A L C Q K Y P R K H S V M M
Dog Lupus familis XP_533723 874 97733 S508 Q N E E M L P S I L V L L K R
Cat Felis silvestris
Mouse Mus musculus Q9QZE5 874 97494 S508 Q N E E M L P S I L V L L K R
Rat Rattus norvegicus Q4AEF8 874 97595 S508 Q N E E M L P S I L V L L K R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511377 871 97400 S508 Q N E N L L P S I L V L L Q R
Chicken Gallus gallus NP_001025768 874 97583 S508 Q N E E M L P S I L V L L K R
Frog Xenopus laevis Q6DKD7 872 97774 S508 Q N E S L L P S V L V L L Q R
Zebra Danio Brachydanio rerio Q9PUE4 873 97510 S508 Q N D D L L P S V L V L M Q R
Tiger Blowfish Takifugu rubipres Q9I8E6 873 97451 S508 Q N D D L L P S V L V L M Q R
Fruit Fly Dros. melanogaster NP_524608 879 97258 N513 S C P A L L S N I L V L L G R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22498 870 96284 S503 Q C V D L R P S I Q V L L K R
Sea Urchin Strong. purpuratus XP_784737 871 96880 S506 H C E E L L P S I V V L L E R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q0WW26 886 98472 R513 M V E S L K P R I T V L L K R
Baker's Yeast Sacchar. cerevisiae P32074 935 104813 Y527 T K N D P T L Y E S I I S L L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 67.8 98.6 N.A. 97.2 97.1 N.A. 81.6 93.3 79.8 81.8 81.4 60.1 N.A. 56.2 70.4
Protein Similarity: 100 99.8 76 99.1 N.A. 98.5 98.4 N.A. 91.7 96.1 90.1 92.2 91.8 74.5 N.A. 75.6 84.2
P-Site Identity: 100 100 0 100 N.A. 100 100 N.A. 80 100 73.3 60 60 46.6 N.A. 60 66.6
P-Site Similarity: 100 100 6.6 100 N.A. 100 100 N.A. 93.3 100 93.3 100 100 60 N.A. 73.3 86.6
Percent
Protein Identity: N.A. N.A. N.A. 51.1 34.3 N.A.
Protein Similarity: N.A. N.A. N.A. 69.8 55.1 N.A.
P-Site Identity: N.A. N.A. N.A. 53.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 19 0 7 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 13 25 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 63 44 0 0 0 0 7 0 0 0 0 7 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % G
% His: 7 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 69 0 7 7 0 0 0 % I
% Lys: 0 7 0 0 0 13 0 0 0 7 0 0 0 50 0 % K
% Leu: 0 0 7 0 50 75 7 0 0 69 0 88 75 7 7 % L
% Met: 7 0 0 0 38 0 0 0 0 0 0 0 13 7 7 % M
% Asn: 0 63 7 7 0 0 0 7 0 0 0 0 0 0 0 % N
% Pro: 0 0 7 0 7 0 82 7 0 0 0 0 0 0 0 % P
% Gln: 69 0 0 0 7 0 0 0 0 7 0 0 0 25 0 % Q
% Arg: 0 0 0 0 0 7 0 7 7 0 0 0 0 0 88 % R
% Ser: 13 0 0 13 0 0 7 75 0 7 0 7 7 0 0 % S
% Thr: 7 0 0 0 0 7 0 0 0 7 0 0 0 0 0 % T
% Val: 0 7 7 0 0 0 0 0 19 7 88 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 7 7 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _