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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP46A1
All Species:
18.79
Human Site:
S179
Identified Species:
34.44
UniProt:
Q9Y6A2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6A2
NP_006659.1
500
56821
S179
A
D
G
Q
T
P
V
S
M
Q
D
M
L
T
Y
Chimpanzee
Pan troglodytes
XP_510158
696
78477
S375
A
D
G
Q
T
P
V
S
M
Q
D
M
L
T
Y
Rhesus Macaque
Macaca mulatta
XP_001103622
505
57211
S184
A
D
G
Q
T
P
V
S
M
Q
D
M
L
T
Y
Dog
Lupus familis
XP_537552
477
54557
D168
M
L
T
C
T
T
M
D
I
L
A
K
A
A
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVK8
500
56796
S179
A
D
G
Q
T
P
V
S
M
Q
D
M
L
T
C
Rat
Rattus norvegicus
P51538
503
57793
S171
S
E
E
G
K
P
T
S
M
K
D
I
F
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512720
452
51454
M171
V
S
M
I
R
N
P
M
L
K
F
L
P
G
K
Chicken
Gallus gallus
XP_421360
499
57589
S181
A
D
G
K
T
E
F
S
M
L
T
M
M
S
R
Frog
Xenopus laevis
NP_001104219
504
58010
K183
A
D
G
K
C
E
T
K
M
H
D
M
L
S
R
Zebra Danio
Brachydanio rerio
NP_001018358
501
57814
V184
A
N
N
K
T
P
A
V
M
H
D
L
V
N
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27589
501
57896
N167
A
D
G
K
T
P
I
N
I
F
P
V
I
C
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780966
507
57852
P186
A
D
G
K
I
E
V
P
M
L
D
E
L
N
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23365
580
65156
D221
G
E
D
T
I
E
L
D
L
E
A
E
F
S
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.4
96.4
87.5
N.A.
94.8
26.4
N.A.
52.5
57.7
51.5
47.3
N.A.
31.3
N.A.
N.A.
40.2
Protein Similarity:
100
71.1
97.4
91.1
N.A.
98.1
47.1
N.A.
68.1
75.4
70
66.4
N.A.
52.5
N.A.
N.A.
59.9
P-Site Identity:
100
100
100
6.6
N.A.
93.3
26.6
N.A.
0
46.6
46.6
33.3
N.A.
33.3
N.A.
N.A.
46.6
P-Site Similarity:
100
100
100
26.6
N.A.
93.3
53.3
N.A.
20
66.6
60
60
N.A.
73.3
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
70
0
0
0
0
0
8
0
0
0
16
0
8
8
8
% A
% Cys:
0
0
0
8
8
0
0
0
0
0
0
0
0
8
16
% C
% Asp:
0
62
8
0
0
0
0
16
0
0
62
0
0
0
0
% D
% Glu:
0
16
8
0
0
31
0
0
0
8
0
16
0
0
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
8
8
0
16
0
8
% F
% Gly:
8
0
62
8
0
0
0
0
0
0
0
0
0
16
0
% G
% His:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
0
% H
% Ile:
0
0
0
8
16
0
8
0
16
0
0
8
8
0
0
% I
% Lys:
0
0
0
39
8
0
0
8
0
16
0
8
0
0
16
% K
% Leu:
0
8
0
0
0
0
8
0
16
24
0
16
47
0
8
% L
% Met:
8
0
8
0
0
0
8
8
70
0
0
47
8
0
0
% M
% Asn:
0
8
8
0
0
8
0
8
0
0
0
0
0
16
0
% N
% Pro:
0
0
0
0
0
54
8
8
0
0
8
0
8
0
0
% P
% Gln:
0
0
0
31
0
0
0
0
0
31
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
16
% R
% Ser:
8
8
0
0
0
0
0
47
0
0
0
0
0
24
8
% S
% Thr:
0
0
8
8
62
8
16
0
0
0
8
0
0
31
0
% T
% Val:
8
0
0
0
0
0
39
8
0
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
24
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _