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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CYP46A1 All Species: 22.12
Human Site: S246 Identified Species: 40.56
UniProt: Q9Y6A2 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y6A2 NP_006659.1 500 56821 S246 Q L R E V R E S I R F L R Q V
Chimpanzee Pan troglodytes XP_510158 696 78477 S442 Q L R E V R E S I R F L R Q V
Rhesus Macaque Macaca mulatta XP_001103622 505 57211 S251 Q L R E V R E S I R F L R Q V
Dog Lupus familis XP_537552 477 54557 D234 F L R Q V G K D W V Q R R R E
Cat Felis silvestris
Mouse Mus musculus Q9WVK8 500 56796 S246 Q L R E I R E S I R L L R Q V
Rat Rattus norvegicus P51538 503 57793 K262 R M K E N R M K E K E K Q R M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512720 452 51454 T235 E G P R D D E T M V D N F I S
Chicken Gallus gallus XP_421360 499 57589 S248 M I K E V Q E S V R L L R R V
Frog Xenopus laevis NP_001104219 504 58010 S250 F I R Q V Q E S I R L L R Q T
Zebra Danio Brachydanio rerio NP_001018358 501 57814 A252 L I Q Q V R E A T E L L R K T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q27589 501 57896 A233 R L T Q P T E A K R Q D K A I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780966 507 57852 A254 M R R S T R K A I H L I R E T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23365 580 65156 C299 D L K I I N D C L D G L I Q N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 70.4 96.4 87.5 N.A. 94.8 26.4 N.A. 52.5 57.7 51.5 47.3 N.A. 31.3 N.A. N.A. 40.2
Protein Similarity: 100 71.1 97.4 91.1 N.A. 98.1 47.1 N.A. 68.1 75.4 70 66.4 N.A. 52.5 N.A. N.A. 59.9
P-Site Identity: 100 100 100 26.6 N.A. 86.6 13.3 N.A. 6.6 53.3 60 33.3 N.A. 20 N.A. N.A. 26.6
P-Site Similarity: 100 100 100 46.6 N.A. 93.3 60 N.A. 26.6 86.6 80 66.6 N.A. 53.3 N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. 23.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 24 0 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 8 8 8 8 0 8 8 8 0 0 0 % D
% Glu: 8 0 0 47 0 0 70 0 8 8 8 0 0 8 8 % E
% Phe: 16 0 0 0 0 0 0 0 0 0 24 0 8 0 0 % F
% Gly: 0 8 0 0 0 8 0 0 0 0 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 0 24 0 8 16 0 0 0 47 0 0 8 8 8 8 % I
% Lys: 0 0 24 0 0 0 16 8 8 8 0 8 8 8 0 % K
% Leu: 8 54 0 0 0 0 0 0 8 0 39 62 0 0 0 % L
% Met: 16 8 0 0 0 0 8 0 8 0 0 0 0 0 8 % M
% Asn: 0 0 0 0 8 8 0 0 0 0 0 8 0 0 8 % N
% Pro: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 31 0 8 31 0 16 0 0 0 0 16 0 8 47 0 % Q
% Arg: 16 8 54 8 0 54 0 0 0 54 0 8 70 24 0 % R
% Ser: 0 0 0 8 0 0 0 47 0 0 0 0 0 0 8 % S
% Thr: 0 0 8 0 8 8 0 8 8 0 0 0 0 0 24 % T
% Val: 0 0 0 0 54 0 0 0 8 16 0 0 0 0 39 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _