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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CYP46A1 All Species: 41.52
Human Site: S360 Identified Species: 76.11
UniProt: Q9Y6A2 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y6A2 NP_006659.1 500 56821 S360 L S Q V L K E S L R L Y P P A
Chimpanzee Pan troglodytes XP_510158 696 78477 S556 L S Q V L K E S L R L Y P P A
Rhesus Macaque Macaca mulatta XP_001103622 505 57211 S365 L S Q V L K E S L R L Y P P A
Dog Lupus familis XP_537552 477 54557 S338 L S Q V L K E S L R L Y P P A
Cat Felis silvestris
Mouse Mus musculus Q9WVK8 500 56796 S360 L S Q V L K E S L R L Y P P A
Rat Rattus norvegicus P51538 503 57793 T363 L D M V V N E T L R L Y P I A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512720 452 51454 D325 L D K E L V V D G I R L P A H
Chicken Gallus gallus XP_421360 499 57589 S364 L S Q V L K E S M R L Y P P V
Frog Xenopus laevis NP_001104219 504 58010 S366 L S Q V L K E S L R L Y P T A
Zebra Danio Brachydanio rerio NP_001018358 501 57814 T371 L S Q V L K E T L R L Y P T A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q27589 501 57896 S371 M E N V I K E S L R L H P P V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780966 507 57852 T373 M M R V L K E T L R L Y S P V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23365 580 65156 P424 L R L F P Q P P L L I R R T L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 70.4 96.4 87.5 N.A. 94.8 26.4 N.A. 52.5 57.7 51.5 47.3 N.A. 31.3 N.A. N.A. 40.2
Protein Similarity: 100 71.1 97.4 91.1 N.A. 98.1 47.1 N.A. 68.1 75.4 70 66.4 N.A. 52.5 N.A. N.A. 59.9
P-Site Identity: 100 100 100 100 N.A. 100 60 N.A. 20 86.6 93.3 86.6 N.A. 60 N.A. N.A. 60
P-Site Similarity: 100 100 100 100 N.A. 100 73.3 N.A. 26.6 93.3 93.3 93.3 N.A. 80 N.A. N.A. 80
Percent
Protein Identity: N.A. N.A. N.A. 23.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 62 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 16 0 0 0 0 0 8 0 0 0 0 0 0 0 % D
% Glu: 0 8 0 8 0 0 85 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % H
% Ile: 0 0 0 0 8 0 0 0 0 8 8 0 0 8 0 % I
% Lys: 0 0 8 0 0 77 0 0 0 0 0 0 0 0 0 % K
% Leu: 85 0 8 0 77 0 0 0 85 8 85 8 0 0 8 % L
% Met: 16 8 8 0 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 8 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 0 8 8 0 0 0 0 85 62 0 % P
% Gln: 0 0 62 0 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 8 8 0 0 0 0 0 0 85 8 8 8 0 0 % R
% Ser: 0 62 0 0 0 0 0 62 0 0 0 0 8 0 0 % S
% Thr: 0 0 0 0 0 0 0 24 0 0 0 0 0 24 0 % T
% Val: 0 0 0 85 8 8 8 0 0 0 0 0 0 0 24 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 77 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _