KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP46A1
All Species:
13.64
Human Site:
T114
Identified Species:
25
UniProt:
Q9Y6A2
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6A2
NP_006659.1
500
56821
T114
K
M
Y
R
A
L
Q
T
V
F
G
E
R
L
F
Chimpanzee
Pan troglodytes
XP_510158
696
78477
T310
K
M
Y
R
A
L
Q
T
V
F
G
E
R
L
F
Rhesus Macaque
Macaca mulatta
XP_001103622
505
57211
T119
K
M
Y
R
A
L
Q
T
V
F
G
E
R
L
F
Dog
Lupus familis
XP_537552
477
54557
E106
F
G
Q
G
L
V
S
E
C
D
Y
E
R
W
H
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVK8
500
56796
T114
K
M
Y
R
A
L
Q
T
V
F
G
E
R
L
F
Rat
Rattus norvegicus
P51538
503
57793
R106
Y
S
T
F
T
N
R
R
N
F
G
P
V
G
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512720
452
51454
I109
K
A
E
Q
L
M
E
I
L
E
E
K
A
D
G
Chicken
Gallus gallus
XP_421360
499
57589
N116
L
V
Y
G
R
I
F
N
L
F
G
V
R
F
L
Frog
Xenopus laevis
NP_001104219
504
58010
N118
R
F
Y
D
V
I
A
N
M
F
G
V
R
F
M
Zebra Danio
Brachydanio rerio
NP_001018358
501
57814
N119
F
V
Y
K
Q
L
F
N
L
F
G
K
R
F
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27589
501
57896
N107
N
N
L
Y
K
L
L
N
C
W
L
G
D
G
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780966
507
57852
K121
E
I
Y
H
G
F
Q
K
L
Y
G
E
R
F
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23365
580
65156
L148
F
S
Y
D
K
G
V
L
A
E
I
L
E
P
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.4
96.4
87.5
N.A.
94.8
26.4
N.A.
52.5
57.7
51.5
47.3
N.A.
31.3
N.A.
N.A.
40.2
Protein Similarity:
100
71.1
97.4
91.1
N.A.
98.1
47.1
N.A.
68.1
75.4
70
66.4
N.A.
52.5
N.A.
N.A.
59.9
P-Site Identity:
100
100
100
13.3
N.A.
100
13.3
N.A.
6.6
26.6
26.6
33.3
N.A.
6.6
N.A.
N.A.
33.3
P-Site Similarity:
100
100
100
20
N.A.
100
20
N.A.
40
46.6
46.6
60
N.A.
13.3
N.A.
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
31
0
8
0
8
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
0
% C
% Asp:
0
0
0
16
0
0
0
0
0
8
0
0
8
8
0
% D
% Glu:
8
0
8
0
0
0
8
8
0
16
8
47
8
0
0
% E
% Phe:
24
8
0
8
0
8
16
0
0
62
0
0
0
31
31
% F
% Gly:
0
8
0
16
8
8
0
0
0
0
70
8
0
16
8
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
8
0
0
0
16
0
8
0
0
8
0
0
0
16
% I
% Lys:
39
0
0
8
16
0
0
8
0
0
0
16
0
0
0
% K
% Leu:
8
0
8
0
16
47
8
8
31
0
8
8
0
31
24
% L
% Met:
0
31
0
0
0
8
0
0
8
0
0
0
0
0
16
% M
% Asn:
8
8
0
0
0
8
0
31
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% P
% Gln:
0
0
8
8
8
0
39
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
31
8
0
8
8
0
0
0
0
70
0
0
% R
% Ser:
0
16
0
0
0
0
8
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
8
0
8
0
0
31
0
0
0
0
0
0
0
% T
% Val:
0
16
0
0
8
8
8
0
31
0
0
16
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% W
% Tyr:
8
0
70
8
0
0
0
0
0
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _