KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP46A1
All Species:
29.39
Human Site:
T370
Identified Species:
53.89
UniProt:
Q9Y6A2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6A2
NP_006659.1
500
56821
T370
L
Y
P
P
A
W
G
T
F
R
L
L
E
E
E
Chimpanzee
Pan troglodytes
XP_510158
696
78477
T566
L
Y
P
P
A
W
G
T
F
R
L
L
E
E
E
Rhesus Macaque
Macaca mulatta
XP_001103622
505
57211
T375
L
Y
P
P
A
W
G
T
F
R
L
L
E
E
E
Dog
Lupus familis
XP_537552
477
54557
T348
L
Y
P
P
A
W
G
T
F
R
L
L
E
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVK8
500
56796
T370
L
Y
P
P
A
W
G
T
F
R
L
L
E
E
E
Rat
Rattus norvegicus
P51538
503
57793
L373
L
Y
P
I
A
G
R
L
E
R
V
C
K
T
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512720
452
51454
I335
R
L
P
A
H
T
S
I
F
L
S
S
Y
T
T
Chicken
Gallus gallus
XP_421360
499
57589
T374
L
Y
P
P
V
P
G
T
V
R
W
T
G
K
E
Frog
Xenopus laevis
NP_001104219
504
58010
T376
L
Y
P
T
A
P
G
T
S
R
W
L
K
E
D
Zebra Danio
Brachydanio rerio
NP_001018358
501
57814
T381
L
Y
P
T
A
P
G
T
N
R
W
L
H
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27589
501
57896
I381
L
H
P
P
V
P
M
I
G
R
W
F
A
E
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780966
507
57852
T383
L
Y
S
P
V
G
G
T
T
R
L
T
A
H
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23365
580
65156
E434
I
R
R
T
L
K
P
E
T
L
P
G
G
H
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.4
96.4
87.5
N.A.
94.8
26.4
N.A.
52.5
57.7
51.5
47.3
N.A.
31.3
N.A.
N.A.
40.2
Protein Similarity:
100
71.1
97.4
91.1
N.A.
98.1
47.1
N.A.
68.1
75.4
70
66.4
N.A.
52.5
N.A.
N.A.
59.9
P-Site Identity:
100
100
100
100
N.A.
100
33.3
N.A.
13.3
53.3
60
60
N.A.
33.3
N.A.
N.A.
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
53.3
N.A.
13.3
60
73.3
66.6
N.A.
46.6
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
62
0
0
0
0
0
0
0
16
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
31
% D
% Glu:
0
0
0
0
0
0
0
8
8
0
0
0
39
62
47
% E
% Phe:
0
0
0
0
0
0
0
0
47
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
16
70
0
8
0
0
8
16
0
0
% G
% His:
0
8
0
0
8
0
0
0
0
0
0
0
8
16
0
% H
% Ile:
8
0
0
8
0
0
0
16
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
8
0
0
0
0
0
0
16
8
8
% K
% Leu:
85
8
0
0
8
0
0
8
0
16
47
54
0
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
85
62
0
31
8
0
0
0
8
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
8
8
0
0
0
8
0
0
85
0
0
0
0
0
% R
% Ser:
0
0
8
0
0
0
8
0
8
0
8
8
0
0
0
% S
% Thr:
0
0
0
24
0
8
0
70
16
0
0
16
0
16
8
% T
% Val:
0
0
0
0
24
0
0
0
8
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
39
0
0
0
0
31
0
0
0
0
% W
% Tyr:
0
77
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _