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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP46A1
All Species:
34.24
Human Site:
T475
Identified Species:
62.78
UniProt:
Q9Y6A2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6A2
NP_006659.1
500
56821
T475
F
G
L
Q
E
Q
A
T
L
K
P
L
D
P
V
Chimpanzee
Pan troglodytes
XP_510158
696
78477
T671
F
G
L
Q
E
Q
A
T
L
K
P
L
D
P
V
Rhesus Macaque
Macaca mulatta
XP_001103622
505
57211
T480
F
G
L
Q
E
Q
A
T
L
K
P
L
D
P
V
Dog
Lupus familis
XP_537552
477
54557
T453
Y
G
L
Q
E
Q
A
T
L
K
P
L
D
P
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVK8
500
56796
T475
F
G
L
Q
E
Q
A
T
L
K
P
L
D
P
V
Rat
Rattus norvegicus
P51538
503
57793
L482
L
K
L
S
K
Q
G
L
L
Q
P
E
K
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512720
452
51454
S419
F
T
I
L
D
T
G
S
L
R
P
K
D
G
V
Chicken
Gallus gallus
XP_421360
499
57589
T479
F
K
L
L
D
T
G
T
L
R
P
L
D
G
V
Frog
Xenopus laevis
NP_001104219
504
58010
T481
F
K
I
L
D
T
G
T
L
R
P
L
D
G
V
Zebra Danio
Brachydanio rerio
NP_001018358
501
57814
E470
A
K
L
L
Q
R
F
E
F
S
L
V
P
G
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27589
501
57896
S482
L
G
P
E
P
R
H
S
M
N
I
V
L
R
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780966
507
57852
S484
F
R
L
E
Q
S
Q
S
M
G
I
L
D
E
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23365
580
65156
T553
F
D
V
E
L
R
G
T
P
E
S
V
E
L
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.4
96.4
87.5
N.A.
94.8
26.4
N.A.
52.5
57.7
51.5
47.3
N.A.
31.3
N.A.
N.A.
40.2
Protein Similarity:
100
71.1
97.4
91.1
N.A.
98.1
47.1
N.A.
68.1
75.4
70
66.4
N.A.
52.5
N.A.
N.A.
59.9
P-Site Identity:
100
100
100
93.3
N.A.
100
33.3
N.A.
33.3
53.3
46.6
6.6
N.A.
6.6
N.A.
N.A.
26.6
P-Site Similarity:
100
100
100
100
N.A.
100
53.3
N.A.
60
66.6
66.6
26.6
N.A.
40
N.A.
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
39
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
24
0
0
0
0
0
0
0
70
0
0
% D
% Glu:
0
0
0
24
39
0
0
8
0
8
0
8
8
8
0
% E
% Phe:
70
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% F
% Gly:
0
47
0
0
0
0
39
0
0
8
0
0
0
31
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
16
0
0
0
0
0
0
0
16
0
0
0
0
% I
% Lys:
0
31
0
0
8
0
0
0
0
39
0
8
8
0
0
% K
% Leu:
16
0
70
31
8
0
0
8
70
0
8
62
8
8
16
% L
% Met:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
8
0
8
0
0
0
8
0
70
0
8
47
0
% P
% Gln:
0
0
0
39
16
47
8
0
0
8
0
0
0
0
8
% Q
% Arg:
0
8
0
0
0
24
0
0
0
24
0
0
0
8
0
% R
% Ser:
0
0
0
8
0
8
0
24
0
8
8
0
0
0
8
% S
% Thr:
0
8
0
0
0
24
0
62
0
0
0
0
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
0
0
0
24
0
0
70
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _