KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP46A1
All Species:
21.21
Human Site:
Y131
Identified Species:
38.89
UniProt:
Q9Y6A2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6A2
NP_006659.1
500
56821
Y131
G
L
V
S
E
C
N
Y
E
R
W
H
K
Q
R
Chimpanzee
Pan troglodytes
XP_510158
696
78477
Y327
G
L
V
S
E
C
N
Y
E
R
W
H
K
Q
R
Rhesus Macaque
Macaca mulatta
XP_001103622
505
57211
Y136
G
L
V
S
E
C
N
Y
E
R
W
H
K
Q
R
Dog
Lupus familis
XP_537552
477
54557
F123
R
R
V
M
D
L
A
F
S
R
S
S
L
V
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVK8
500
56796
Y131
G
L
V
S
E
C
D
Y
G
R
W
Y
K
Q
R
Rat
Rattus norvegicus
P51538
503
57793
D123
K
A
I
S
I
S
E
D
E
E
W
K
R
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512720
452
51454
M126
E
V
S
L
L
N
M
M
N
R
V
T
L
D
I
Chicken
Gallus gallus
XP_421360
499
57589
Y133
G
L
V
T
D
R
N
Y
E
H
W
H
K
Q
R
Frog
Xenopus laevis
NP_001104219
504
58010
Y135
G
L
V
T
D
R
D
Y
D
H
W
H
K
Q
R
Zebra Danio
Brachydanio rerio
NP_001018358
501
57814
H136
G
L
I
T
A
V
D
H
D
M
W
Y
R
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27589
501
57896
G124
S
T
G
R
K
W
H
G
R
R
K
I
I
T
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780966
507
57852
H138
G
L
V
S
E
V
D
H
E
K
W
F
H
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23365
580
65156
L165
K
G
L
I
P
A
D
L
D
T
W
K
L
R
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
70.4
96.4
87.5
N.A.
94.8
26.4
N.A.
52.5
57.7
51.5
47.3
N.A.
31.3
N.A.
N.A.
40.2
Protein Similarity:
100
71.1
97.4
91.1
N.A.
98.1
47.1
N.A.
68.1
75.4
70
66.4
N.A.
52.5
N.A.
N.A.
59.9
P-Site Identity:
100
100
100
13.3
N.A.
80
26.6
N.A.
6.6
73.3
60
33.3
N.A.
6.6
N.A.
N.A.
53.3
P-Site Similarity:
100
100
100
26.6
N.A.
93.3
40
N.A.
13.3
86.6
86.6
80
N.A.
20
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
8
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
31
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
24
0
39
8
24
0
0
0
0
8
0
% D
% Glu:
8
0
0
0
39
0
8
0
47
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
0
% F
% Gly:
62
8
8
0
0
0
0
8
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
16
0
16
0
39
8
0
0
% H
% Ile:
0
0
16
8
8
0
0
0
0
0
0
8
8
8
8
% I
% Lys:
16
0
0
0
8
0
0
0
0
8
8
16
47
0
0
% K
% Leu:
0
62
8
8
8
8
0
8
0
0
0
0
24
0
0
% L
% Met:
0
0
0
8
0
0
8
8
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
31
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
54
0
% Q
% Arg:
8
8
0
8
0
16
0
0
8
54
0
0
16
16
77
% R
% Ser:
8
0
8
47
0
8
0
0
8
0
8
8
0
0
8
% S
% Thr:
0
8
0
24
0
0
0
0
0
8
0
8
0
8
0
% T
% Val:
0
8
62
0
0
16
0
0
0
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
77
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
47
0
0
0
16
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _